fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin

Interactions between melanocytes and neighboring cells in the skin are important in regulating skin color in humans. We recently demonstrated that the less pigmented and thicker skin on the palms and soles is regulated by underlying fibroblasts in those areas, specifically via a secreted factor (DKK...

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Veröffentlicht in:	Journal of cell science 2010-09, Vol.123 (18), p.3102-3111
Hauptverfasser:	Choi, Wonseon, Wolber, Rainer, Gerwat, Wolfram, Mann, Tobias, Batzer, Jan, Smuda, Christoph, Liu, Hongfang, Kolbe, Ludger, Hearing, Vincent J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cells, Cultured Fibroblasts - metabolism Gene Expression Regulation Humans Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Melanocytes - metabolism Neuregulin-1 - genetics Neuregulin-1 - metabolism Skin - metabolism Skin Pigmentation
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