PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells

Proteasome inhibitor PS-341 (also known as bortezomib) and histone deacetylase (HDAC) inhibitors have emerged as novel therapeutic agents for a variety of malignancies. In this study, we examined whether PS-341 and the HDAC inhibitor trichostatin A (TSA) induced apoptosis in head and neck squamous c...

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Veröffentlicht in:	Molecular cancer therapeutics 2010-07, Vol.9 (7), p.1977-1984
Hauptverfasser:	Kim, Jinkoo, Guan, Jean, Chang, Insoon, Chen, Xiaohong, Han, Demin, Wang, Cun-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation - drug effects Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis - drug effects Blotting, Northern Blotting, Western Boronic Acids - administration & dosage Boronic Acids - pharmacology Bortezomib Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Caspases - metabolism Cell Line, Tumor Dose-Response Relationship, Drug Drug Synergism Enzyme Activation - drug effects Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Histone Deacetylase Inhibitors - administration & dosage Histone Deacetylase Inhibitors - pharmacology Histones - metabolism Humans Hydroxamic Acids - administration & dosage Hydroxamic Acids - pharmacology Mice Mice, Nude Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Pyrazines - administration & dosage Pyrazines - pharmacology RNA Interference Xenograft Model Antitumor Assays
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