In vivo prevention of transplant arteriosclerosis by ex vivo -expanded human regulatory T cells

Transplant arteriosclerosis is the hallmark of chronic allograft dysfunction (CAD) affecting transplanted organs in the long term. These fibroproliferative lesions lead to neointimal thickening of arteries in all transplanted allografts. Luminal narrowing then leads to graft ischemia and organ demis...

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Veröffentlicht in:	Nature medicine 2010-07, Vol.16 (7), p.809-813
Hauptverfasser:	Wood, Kathryn J, Nadig, Satish N, Schiopu, Alexandru, Wu, Douglas C, Zhang, Wei, Taggart, David P, Wi ckiewicz, Joanna, Luo, Shiqiao, Warnecke, Gregor
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1619/554/1898/1271 631/61/51/1844 692/699/75/593 Animals Aorta, Abdominal - surgery Arteriosclerosis Arteriosclerosis - immunology Arteriosclerosis - prevention & control Biomedical and Life Sciences Biomedicine Cancer Research Cardiology Care and treatment CD4-Positive T-Lymphocytes - immunology Cell Separation Cellular biology Graft Rejection Health aspects Hypothesis testing Infectious Diseases Infiltration Interferon-gamma - metabolism Interleukin-2 Receptor alpha Subunit - metabolism Interleukin-7 Receptor alpha Subunit - metabolism Lesions letter Leukocytes, Mononuclear - transplantation Mammary Arteries - transplantation Metabolic Diseases Mice Mice, Inbred BALB C Molecular Medicine Neurosciences Organ transplant recipients Physiological aspects Risk factors T cells T-Lymphocytes, Regulatory - immunology Transplants & implants Veins & arteries
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