Rhodium-Catalyzed Oxidative Cycloaddition of Benzamides and Alkynes via C−H/N−H Activation

The oxidative cycloaddition of benzamides and alkynes has been developed. The reaction utilizes Rh(III) catalysts in the presence of Cu(II) oxidants, and is proposed to proceed by N−H metalation of the amide followed by ortho C−H activation. The resultant rhodacycle undergoes alkyne insertion to for...

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Veröffentlicht in:	Journal of the American Chemical Society 2010-08, Vol.132 (30), p.10565-10569
Hauptverfasser:	Hyster, Todd K, Rovis, Tomislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Benzamides - chemistry Catalysis Cyclization Oxidation-Reduction Rhodium - chemistry
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container_title	Journal of the American Chemical Society
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creator	Hyster, Todd K Rovis, Tomislav
description	The oxidative cycloaddition of benzamides and alkynes has been developed. The reaction utilizes Rh(III) catalysts in the presence of Cu(II) oxidants, and is proposed to proceed by N−H metalation of the amide followed by ortho C−H activation. The resultant rhodacycle undergoes alkyne insertion to form isoquinolones in good yield. The reaction is tolerant of extensive substitution on the amide, alkyne, and arene, including halides, silyl ethers, and unprotected aldehydes as substituents. Unsymmetrical alkynes proceed with excellent regioselectivity, and heteroaryl carboxamides are tolerated leading to intriguing scaffolds for medicinal chemistry. A series of competition experiments shed further light on the mechanism of the transformation and reasons for selectivity.
doi_str_mv	10.1021/ja103776u
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subjects	Alkynes - chemistry Benzamides - chemistry Catalysis Cyclization Oxidation-Reduction Rhodium - chemistry
title	Rhodium-Catalyzed Oxidative Cycloaddition of Benzamides and Alkynes via C−H/N−H Activation
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