p38γ mitogen-activated protein kinase suppresses chondrocyte production of MMP-13 in response to catabolic stimulation

Summary Objective The signaling protein p38 mitogen-activated protein kinase is required for inflammatory signaling in chondrocytes that regulates matrix metalloproteinase (MMP) production. We sought to determine the role of specific p38 isoforms in chondrocyte catabolic signaling in response to IL-...

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Veröffentlicht in:	Osteoarthritis and cartilage 2010-09, Vol.18 (9), p.1203-1210
Hauptverfasser:	Long, D.L, Loeser, R.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Articular cartilage Cell signaling Chondrocyte Cytokines Integrins Matrix metalloproteinase Rheumatology
Online-Zugang:	Volltext
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