RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter

The sodium-chloride cotransporter (NCC) is the principal salt-absorptive pathway in the distal convoluted tubule. Recently, we described a novel pathway of NCC regulation in which phorbol esters (PE) stimulate Ras guanyl-releasing protein 1 (RasGRP1), triggering a cascade ultimately activating ERK1/...

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Veröffentlicht in:	American Journal of Physiology - Renal Physiology 2010-08, Vol.299 (2), p.F300-F309
Hauptverfasser:	Ko, Benjamin, Kamsteeg, Erik-Jan, Cooke, Leslie L, Moddes, Lauren N, Deen, Peter M T, Hoover, Robert S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biotinylation Blotting, Western Cell Line Cells Dogs Dynamins - genetics Dynamins - metabolism Endocytosis Endocytosis - drug effects Enzyme Activation Enzyme Activators - pharmacology Gene expression Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Immunoprecipitation Kidney Tubules, Distal - drug effects Kidney Tubules, Distal - metabolism MAP Kinase Kinase 1 - antagonists & inhibitors MAP Kinase Kinase 1 - metabolism MAP Kinase Kinase 2 - antagonists & inhibitors MAP Kinase Kinase 2 - metabolism Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Protein Kinase Inhibitors - pharmacology Protein Processing, Post-Translational - drug effects Protein Transport Receptors, Drug - drug effects Receptors, Drug - genetics Receptors, Drug - metabolism Solute Carrier Family 12, Member 3 Symporters - drug effects Symporters - genetics Symporters - metabolism Tetradecanoylphorbol Acetate - pharmacology Transfection Ubiquitin-Activating Enzymes - antagonists & inhibitors Ubiquitin-Activating Enzymes - metabolism Ubiquitination Up-Regulation Vitamin B
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