Differentiation and Persistence of Memory CD8 + T Cells Depend on T Cell Factor 1

T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the canonical Wnt pathway and is essential for normal T cell development. However, its physiological roles in mature CD8 + T cell responses are unknown. Here we showed that TCF-1 deficiency limited proliferation of CD8 + ef...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2010-08, Vol.33 (2), p.229-240
Hauptverfasser:	Zhou, Xinyuan, Yu, Shuyang, Zhao, Dong-Mei, Harty, John T., Badovinac, Vladimir P., Xue, Hai-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis beta Catenin - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Differentiation CELLIMMUNO Colleges & universities Flow cytometry Gene expression Gene Expression Regulation Hepatocyte Nuclear Factor 1-alpha Immunologic Memory Infections Interleukin-15 - immunology Kinases Listeria Listeria monocytogenes - immunology Lymphocytes Mice Mice, Inbred C57BL Mice, Knockout MOLIMMUNO Phenotype Protein Binding Regulatory Sequences, Nucleic Acid Rodents Signal Transduction T Cell Transcription Factor 1 - deficiency T Cell Transcription Factor 1 - immunology T Cell Transcription Factor 1 - metabolism T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism Transcription, Genetic Wnt Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!