Doses of Insulin and Its Analogues and Cancer Occurrence in Insulin-Treated Type 2 Diabetic Patients

OBJECTIVE: Recent epidemiological studies suggested that some insulin analogues could be associated with increased risk of cancer. The present study is aimed at assessing the long-term association of different insulin analogues with cancer incidence. RESEARCH DESIGN AND METHODS: A nested case-contro...

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Veröffentlicht in:	Diabetes care 2010-09, Vol.33 (9), p.1997-2003
Hauptverfasser:	Mannucci, Edoardo, Monami, Matteo, Balzi, Daniela, Cresci, Barbara, Pala, Laura, Melani, Cecilia, Lamanna, Caterina, Bracali, Ilaria, Bigiarini, Michela, Barchielli, Alessandro, Marchionni, Niccolo, Rotella, Carlo Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biological and medical sciences Cancer Cancer therapies Care and treatment Case-Control Studies Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes. Impaired glucose tolerance Diabetics Drug Administration Schedule Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Family medical history Fees & charges Female Heterocyclic compounds Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Insulin Insulin - administration & dosage Insulin - adverse effects Insulin - analogs & derivatives Insulin - therapeutic use Insulin Glargine Insulin, Long-Acting Male Medical sciences Metabolic diseases Middle Aged Miscellaneous Mortality Neoplasms - epidemiology Neoplasms - etiology Oncology, Experimental Original Research Pharmaceutical industry Public health. Hygiene Public health. Hygiene-occupational medicine Studies Teaching hospitals
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Zusammenfassung:	OBJECTIVE: Recent epidemiological studies suggested that some insulin analogues could be associated with increased risk of cancer. The present study is aimed at assessing the long-term association of different insulin analogues with cancer incidence. RESEARCH DESIGN AND METHODS: A nested case-control study dataset was generated from the cohort study dataset (n = 1,340 insulin-treated diabetic outpatients) by sampling control subjects from the risk sets. For each case subject, the control subjects (up to five) were chosen randomly from those members of the cohort who are at risk for the same follow-up time of the case subject. Five-year age classes, sex, and BMI classes (
ISSN:	0149-5992 1935-5548
DOI:	10.2337/dc10-0476