Radiation dose optimized lateral expansion of the field of view in synchrotron radiation X-ray tomographic microscopy
Volumetric data at micrometer level resolution can be acquired within a few minutes using synchrotron‐radiation‐based tomographic microscopy. The field of view along the rotation axis of the sample can easily be increased by stacking several tomograms, allowing the investigation of long and thin obj...
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| Veröffentlicht in: | Journal of synchrotron radiation 2010-09, Vol.17 (5), p.590-599 |
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| creator | Haberthür, David Hintermüller, Christoph Marone, Federica Schittny, Johannes C. Stampanoni, Marco |
| description | Volumetric data at micrometer level resolution can be acquired within a few minutes using synchrotron‐radiation‐based tomographic microscopy. The field of view along the rotation axis of the sample can easily be increased by stacking several tomograms, allowing the investigation of long and thin objects at high resolution. On the contrary, an extension of the field of view in the perpendicular direction is non‐trivial. This paper presents an acquisition protocol which increases the field of view of the tomographic dataset perpendicular to its rotation axis. The acquisition protocol can be tuned as a function of the reconstruction quality and scanning time. Since the scanning time is proportional to the radiation dose imparted to the sample, this method can be used to increase the field of view of tomographic microscopy instruments while optimizing the radiation dose for radiation‐sensitive samples and keeping the quality of the tomographic dataset on the required level. This approach, dubbed wide‐field synchrotron radiation tomographic microscopy, can increase the lateral field of view up to five times. The method has been successfully applied for the three‐dimensional imaging of entire rat lung acini with a diameter of 4.1 mm at a voxel size of 1.48 µm. |
| doi_str_mv | 10.1107/S0909049510019618 |
| format | Article |
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The field of view along the rotation axis of the sample can easily be increased by stacking several tomograms, allowing the investigation of long and thin objects at high resolution. On the contrary, an extension of the field of view in the perpendicular direction is non‐trivial. This paper presents an acquisition protocol which increases the field of view of the tomographic dataset perpendicular to its rotation axis. The acquisition protocol can be tuned as a function of the reconstruction quality and scanning time. Since the scanning time is proportional to the radiation dose imparted to the sample, this method can be used to increase the field of view of tomographic microscopy instruments while optimizing the radiation dose for radiation‐sensitive samples and keeping the quality of the tomographic dataset on the required level. This approach, dubbed wide‐field synchrotron radiation tomographic microscopy, can increase the lateral field of view up to five times. 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Synchrotron Rad</addtitle><description>Volumetric data at micrometer level resolution can be acquired within a few minutes using synchrotron‐radiation‐based tomographic microscopy. The field of view along the rotation axis of the sample can easily be increased by stacking several tomograms, allowing the investigation of long and thin objects at high resolution. On the contrary, an extension of the field of view in the perpendicular direction is non‐trivial. This paper presents an acquisition protocol which increases the field of view of the tomographic dataset perpendicular to its rotation axis. The acquisition protocol can be tuned as a function of the reconstruction quality and scanning time. Since the scanning time is proportional to the radiation dose imparted to the sample, this method can be used to increase the field of view of tomographic microscopy instruments while optimizing the radiation dose for radiation‐sensitive samples and keeping the quality of the tomographic dataset on the required level. This approach, dubbed wide‐field synchrotron radiation tomographic microscopy, can increase the lateral field of view up to five times. The method has been successfully applied for the three‐dimensional imaging of entire rat lung acini with a diameter of 4.1 mm at a voxel size of 1.48 µm.</description><subject>acinus</subject><subject>Acquisitions</subject><subject>alveoli</subject><subject>Animals</subject><subject>computed tomography</subject><subject>Field of view</subject><subject>Image Processing, Computer-Assisted - methods</subject><subject>Imaging, Three-Dimensional</subject><subject>lung</subject><subject>lung development</subject><subject>Marketing</subject><subject>Micrometers</subject><subject>Microscopy</subject><subject>Optimization</subject><subject>Pulmonary Alveoli - ultrastructure</subject><subject>Radiation Dosage</subject><subject>radiation dose</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Research Papers</subject><subject>Scanning</subject><subject>SRXTM</subject><subject>Stacking</subject><subject>synchrotron microtomography</subject><subject>Synchrotron radiation</subject><subject>Synchrotrons</subject><subject>Tomography, X-Ray Computed - instrumentation</subject><subject>X-ray imaging</subject><issn>1600-5775</issn><issn>0909-0495</issn><issn>1600-5775</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EoqXwAGyQd7AJ2E4cOxskWkFLNSoVw-_KcpzrjiGJg52ZNjwNz8KT4WjKqAgJZFn--86Rz70IPaTkKaVEPFuSKo2i4pQQWpVU3kL7tCQk40Lw2zf2e-hejF8SVAqW30V7jAhWCEn20eatbpwene9x4yNgP4yuc9-hwa0eIegWw9Wg-zgD3uJxBT9_WAdtM582Di6x63GcerMKfgwJCju_T1nQEx595y-CHlbO4M6Z4KPxw3Qf3bG6jfDgej1A71-9fHd0ki3eHL8-erHIDJdFkZmi1IJaA8TWhHAwBRUcrJTU0FpQY6Uudcoi69JqUdc2z2lBgNeMyhIakx-g51vfYV136QL6MWVSQ3CdDpPy2qk_X3q3Uhd-o1jFREVYMnh8bRD8tzXEUXUuGmhb3YNfRyUKWVWE5zKRT_5JptpTVqU5o3SLzuWIAezuQ5SoubPqr84mzaObSXaK361MgNwCl66F6f-O6nT5-fycE1IkabaVujjC1U6qw1dVilxw9fHsWC1PPpwe0rOFYvkvN1zCEA</recordid><startdate>201009</startdate><enddate>201009</enddate><creator>Haberthür, David</creator><creator>Hintermüller, Christoph</creator><creator>Marone, Federica</creator><creator>Schittny, Johannes C.</creator><creator>Stampanoni, Marco</creator><general>International Union of Crystallography</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201009</creationdate><title>Radiation dose optimized lateral expansion of the field of view in synchrotron radiation X-ray tomographic microscopy</title><author>Haberthür, David ; Hintermüller, Christoph ; Marone, Federica ; Schittny, Johannes C. ; Stampanoni, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5844-c46a71fce0fb005ec4175ef881c1b71cf8a6a0728b6fa7bbf33140e5b2186edc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>acinus</topic><topic>Acquisitions</topic><topic>alveoli</topic><topic>Animals</topic><topic>computed tomography</topic><topic>Field of view</topic><topic>Image Processing, Computer-Assisted - methods</topic><topic>Imaging, Three-Dimensional</topic><topic>lung</topic><topic>lung development</topic><topic>Marketing</topic><topic>Micrometers</topic><topic>Microscopy</topic><topic>Optimization</topic><topic>Pulmonary Alveoli - ultrastructure</topic><topic>Radiation Dosage</topic><topic>radiation dose</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Research Papers</topic><topic>Scanning</topic><topic>SRXTM</topic><topic>Stacking</topic><topic>synchrotron microtomography</topic><topic>Synchrotron radiation</topic><topic>Synchrotrons</topic><topic>Tomography, X-Ray Computed - instrumentation</topic><topic>X-ray imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Haberthür, David</creatorcontrib><creatorcontrib>Hintermüller, Christoph</creatorcontrib><creatorcontrib>Marone, Federica</creatorcontrib><creatorcontrib>Schittny, Johannes C.</creatorcontrib><creatorcontrib>Stampanoni, Marco</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of synchrotron radiation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Haberthür, David</au><au>Hintermüller, Christoph</au><au>Marone, Federica</au><au>Schittny, Johannes C.</au><au>Stampanoni, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiation dose optimized lateral expansion of the field of view in synchrotron radiation X-ray tomographic microscopy</atitle><jtitle>Journal of synchrotron radiation</jtitle><addtitle>J. Synchrotron Rad</addtitle><date>2010-09</date><risdate>2010</risdate><volume>17</volume><issue>5</issue><spage>590</spage><epage>599</epage><pages>590-599</pages><issn>1600-5775</issn><issn>0909-0495</issn><eissn>1600-5775</eissn><abstract>Volumetric data at micrometer level resolution can be acquired within a few minutes using synchrotron‐radiation‐based tomographic microscopy. The field of view along the rotation axis of the sample can easily be increased by stacking several tomograms, allowing the investigation of long and thin objects at high resolution. On the contrary, an extension of the field of view in the perpendicular direction is non‐trivial. This paper presents an acquisition protocol which increases the field of view of the tomographic dataset perpendicular to its rotation axis. The acquisition protocol can be tuned as a function of the reconstruction quality and scanning time. 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| subjects | acinus Acquisitions alveoli Animals computed tomography Field of view Image Processing, Computer-Assisted - methods Imaging, Three-Dimensional lung lung development Marketing Micrometers Microscopy Optimization Pulmonary Alveoli - ultrastructure Radiation Dosage radiation dose Rats Rats, Sprague-Dawley Research Papers Scanning SRXTM Stacking synchrotron microtomography Synchrotron radiation Synchrotrons Tomography, X-Ray Computed - instrumentation X-ray imaging |
| title | Radiation dose optimized lateral expansion of the field of view in synchrotron radiation X-ray tomographic microscopy |
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