The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin
Abstract Lysophophatidylcholine (LPC) and lysophosphatidic acid (LPA) are potent lysolipid mediators increasingly linked with atherosclerosis and inflammation. A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in...
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| Veröffentlicht in: | Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2010-02, Vol.82 (2), p.87-95 |
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| container_title | Prostaglandins, leukotrienes and essential fatty acids |
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| creator | Block, R.C Duff, R Lawrence, P Kakinami, L Brenna, J.T Shearer, G.C Meednu, N Mousa, S Friedman, A Harris, W.S Larson, Mark Georas, S |
| description | Abstract Lysophophatidylcholine (LPC) and lysophosphatidic acid (LPA) are potent lysolipid mediators increasingly linked with atherosclerosis and inflammation. A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in human subjects. We conducted a clinical trial of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and aspirin ingestion in normal volunteers. Fasting blood samples were drawn at baseline and after 4-week supplementation with EPA/DHA (3.4 g/d) with and without aspirin (650 mg). Plasma LPC and LPA species and autotaxin activity were measured. EPA-LPC and DHA-LPC concentrations increased significantly with EPA/DHA supplementation whereas EPA- and DHA-LPA did not. Autotaxin activity was unaffected by any treatment, and aspirin had no effect on any endpoint. Taken together, our data demonstrate that plasma LPC, but not LPA, species can be dynamically regulated by dietary supplementation, and argue against a simple model of LPA generation via LPC hydrolysis. |
| doi_str_mv | 10.1016/j.plefa.2009.12.005 |
| format | Article |
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A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in human subjects. We conducted a clinical trial of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and aspirin ingestion in normal volunteers. Fasting blood samples were drawn at baseline and after 4-week supplementation with EPA/DHA (3.4 g/d) with and without aspirin (650 mg). Plasma LPC and LPA species and autotaxin activity were measured. EPA-LPC and DHA-LPC concentrations increased significantly with EPA/DHA supplementation whereas EPA- and DHA-LPA did not. Autotaxin activity was unaffected by any treatment, and aspirin had no effect on any endpoint. Taken together, our data demonstrate that plasma LPC, but not LPA, species can be dynamically regulated by dietary supplementation, and argue against a simple model of LPA generation via LPC hydrolysis.</description><identifier>ISSN: 0952-3278</identifier><identifier>EISSN: 1532-2823</identifier><identifier>DOI: 10.1016/j.plefa.2009.12.005</identifier><identifier>PMID: 20106646</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Advanced Basic Science ; Aspirin - pharmacology ; Autotaxin ; Biological and medical sciences ; Dietary Supplements ; Docosahexaenoic acid ; Docosahexaenoic Acids - pharmacology ; Eicosapentaenoic acid ; Eicosapentaenoic Acid - pharmacology ; Endocrinology & Metabolism ; Enzyme Activation - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Lipid Metabolism - drug effects ; Lysophosphatidic acid ; Lysophosphatidylcholine ; Lysophosphatidylcholines - blood ; Lysophospholipase D ; Lysophospholipids - blood ; Male ; Middle Aged ; Models, Biological ; Multienzyme Complexes - blood ; Phosphodiesterase I - blood ; Phosphoric Diester Hydrolases ; Pyrophosphatases - blood ; Vertebrates: endocrinology ; Young Adult</subject><ispartof>Prostaglandins, leukotrienes and essential fatty acids, 2010-02, Vol.82 (2), p.87-95</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><rights>2010 Elsevier Ltd. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c609t-7873a8462ad607b69516a47269dc2cedcabc77113c334478597f4b563240443d3</citedby><cites>FETCH-LOGICAL-c609t-7873a8462ad607b69516a47269dc2cedcabc77113c334478597f4b563240443d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0952327810000190$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22432810$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20106646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Block, R.C</creatorcontrib><creatorcontrib>Duff, R</creatorcontrib><creatorcontrib>Lawrence, P</creatorcontrib><creatorcontrib>Kakinami, L</creatorcontrib><creatorcontrib>Brenna, J.T</creatorcontrib><creatorcontrib>Shearer, G.C</creatorcontrib><creatorcontrib>Meednu, N</creatorcontrib><creatorcontrib>Mousa, S</creatorcontrib><creatorcontrib>Friedman, A</creatorcontrib><creatorcontrib>Harris, W.S</creatorcontrib><creatorcontrib>Larson, Mark</creatorcontrib><creatorcontrib>Georas, S</creatorcontrib><title>The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin</title><title>Prostaglandins, leukotrienes and essential fatty acids</title><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><description>Abstract Lysophophatidylcholine (LPC) and lysophosphatidic acid (LPA) are potent lysolipid mediators increasingly linked with atherosclerosis and inflammation. A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in human subjects. We conducted a clinical trial of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and aspirin ingestion in normal volunteers. Fasting blood samples were drawn at baseline and after 4-week supplementation with EPA/DHA (3.4 g/d) with and without aspirin (650 mg). Plasma LPC and LPA species and autotaxin activity were measured. EPA-LPC and DHA-LPC concentrations increased significantly with EPA/DHA supplementation whereas EPA- and DHA-LPA did not. Autotaxin activity was unaffected by any treatment, and aspirin had no effect on any endpoint. Taken together, our data demonstrate that plasma LPC, but not LPA, species can be dynamically regulated by dietary supplementation, and argue against a simple model of LPA generation via LPC hydrolysis.</description><subject>Adult</subject><subject>Advanced Basic Science</subject><subject>Aspirin - pharmacology</subject><subject>Autotaxin</subject><subject>Biological and medical sciences</subject><subject>Dietary Supplements</subject><subject>Docosahexaenoic acid</subject><subject>Docosahexaenoic Acids - pharmacology</subject><subject>Eicosapentaenoic acid</subject><subject>Eicosapentaenoic Acid - pharmacology</subject><subject>Endocrinology & Metabolism</subject><subject>Enzyme Activation - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lipid Metabolism - drug effects</subject><subject>Lysophosphatidic acid</subject><subject>Lysophosphatidylcholine</subject><subject>Lysophosphatidylcholines - blood</subject><subject>Lysophospholipase D</subject><subject>Lysophospholipids - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Models, Biological</subject><subject>Multienzyme Complexes - blood</subject><subject>Phosphodiesterase I - blood</subject><subject>Phosphoric Diester Hydrolases</subject><subject>Pyrophosphatases - blood</subject><subject>Vertebrates: endocrinology</subject><subject>Young Adult</subject><issn>0952-3278</issn><issn>1532-2823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUk1vEzEQtRCIpoVfgIT2grh0F3-tvT5QKSqBVopEJYrEzXK83sZhYy-eTUX-PV4SyscFyfYc_N68mXmD0AuCK4KJeLOpht51pqIYq4rQCuP6EZqRmtGSNpQ9RjOsaloyKpsTdAqwwRhTQvhTdEIxwUJwMUNfbteuWHSdsyMUsSsWN_Pz4t1VfkxoizkMPvlQXIc7B6OPocjnpjewNcVyD3FYR8i394Nv4cDYjXE03314hp50pgf3_BjP0Of3i9vLq3L58cP15XxZWoHVWMpGMtNwQU0rsFwJVRNhuKRCtZZa11qzslISwixjnMumVrLjq1owyjHnrGVn6OKQd9itthnvwphMr4fktybtdTRe__0T_FrfxXtNVRahKid4fUyQ4rddblNvPVjX9ya4uAMtGVM1lgpnJDsgbYoAyXUPKgTryRK90T8t0ZMlmlCdLcmsl38W-MD55UEGvDoCDFjTd8kE6-E3jnJGGzLJvz3gXB7nvXdJg_Uu5CH5lO3TbfT_KeTiH77tffBZ8qvbO9jEXQrZKU00ZIL-NG3PtDwk7w0muf8fsNO-Xw</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Block, R.C</creator><creator>Duff, R</creator><creator>Lawrence, P</creator><creator>Kakinami, L</creator><creator>Brenna, J.T</creator><creator>Shearer, G.C</creator><creator>Meednu, N</creator><creator>Mousa, S</creator><creator>Friedman, A</creator><creator>Harris, W.S</creator><creator>Larson, Mark</creator><creator>Georas, S</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin</title><author>Block, R.C ; Duff, R ; Lawrence, P ; Kakinami, L ; Brenna, J.T ; Shearer, G.C ; Meednu, N ; Mousa, S ; Friedman, A ; Harris, W.S ; Larson, Mark ; Georas, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c609t-7873a8462ad607b69516a47269dc2cedcabc77113c334478597f4b563240443d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Advanced Basic Science</topic><topic>Aspirin - pharmacology</topic><topic>Autotaxin</topic><topic>Biological and medical sciences</topic><topic>Dietary Supplements</topic><topic>Docosahexaenoic acid</topic><topic>Docosahexaenoic Acids - pharmacology</topic><topic>Eicosapentaenoic acid</topic><topic>Eicosapentaenoic Acid - pharmacology</topic><topic>Endocrinology & Metabolism</topic><topic>Enzyme Activation - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lipid Metabolism - drug effects</topic><topic>Lysophosphatidic acid</topic><topic>Lysophosphatidylcholine</topic><topic>Lysophosphatidylcholines - blood</topic><topic>Lysophospholipase D</topic><topic>Lysophospholipids - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Models, Biological</topic><topic>Multienzyme Complexes - blood</topic><topic>Phosphodiesterase I - blood</topic><topic>Phosphoric Diester Hydrolases</topic><topic>Pyrophosphatases - blood</topic><topic>Vertebrates: endocrinology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Block, R.C</creatorcontrib><creatorcontrib>Duff, R</creatorcontrib><creatorcontrib>Lawrence, P</creatorcontrib><creatorcontrib>Kakinami, L</creatorcontrib><creatorcontrib>Brenna, J.T</creatorcontrib><creatorcontrib>Shearer, G.C</creatorcontrib><creatorcontrib>Meednu, N</creatorcontrib><creatorcontrib>Mousa, S</creatorcontrib><creatorcontrib>Friedman, A</creatorcontrib><creatorcontrib>Harris, W.S</creatorcontrib><creatorcontrib>Larson, Mark</creatorcontrib><creatorcontrib>Georas, S</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Block, R.C</au><au>Duff, R</au><au>Lawrence, P</au><au>Kakinami, L</au><au>Brenna, J.T</au><au>Shearer, G.C</au><au>Meednu, N</au><au>Mousa, S</au><au>Friedman, A</au><au>Harris, W.S</au><au>Larson, Mark</au><au>Georas, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin</atitle><jtitle>Prostaglandins, leukotrienes and essential fatty acids</jtitle><addtitle>Prostaglandins Leukot Essent Fatty Acids</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>82</volume><issue>2</issue><spage>87</spage><epage>95</epage><pages>87-95</pages><issn>0952-3278</issn><eissn>1532-2823</eissn><abstract>Abstract Lysophophatidylcholine (LPC) and lysophosphatidic acid (LPA) are potent lysolipid mediators increasingly linked with atherosclerosis and inflammation. A current model proposing that plasma LPA is produced when LPC is hydrolyzed by the enzyme autotaxin has not been rigorously investigated in human subjects. We conducted a clinical trial of eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) and aspirin ingestion in normal volunteers. Fasting blood samples were drawn at baseline and after 4-week supplementation with EPA/DHA (3.4 g/d) with and without aspirin (650 mg). Plasma LPC and LPA species and autotaxin activity were measured. EPA-LPC and DHA-LPC concentrations increased significantly with EPA/DHA supplementation whereas EPA- and DHA-LPA did not. Autotaxin activity was unaffected by any treatment, and aspirin had no effect on any endpoint. Taken together, our data demonstrate that plasma LPC, but not LPA, species can be dynamically regulated by dietary supplementation, and argue against a simple model of LPA generation via LPC hydrolysis.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>20106646</pmid><doi>10.1016/j.plefa.2009.12.005</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0952-3278 |
| ispartof | Prostaglandins, leukotrienes and essential fatty acids, 2010-02, Vol.82 (2), p.87-95 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Advanced Basic Science Aspirin - pharmacology Autotaxin Biological and medical sciences Dietary Supplements Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Eicosapentaenoic acid Eicosapentaenoic Acid - pharmacology Endocrinology & Metabolism Enzyme Activation - drug effects Female Fundamental and applied biological sciences. Psychology Humans Lipid Metabolism - drug effects Lysophosphatidic acid Lysophosphatidylcholine Lysophosphatidylcholines - blood Lysophospholipase D Lysophospholipids - blood Male Middle Aged Models, Biological Multienzyme Complexes - blood Phosphodiesterase I - blood Phosphoric Diester Hydrolases Pyrophosphatases - blood Vertebrates: endocrinology Young Adult |
| title | The Effects of EPA, DHA, and Aspirin Ingestion on Plasma Lysophospholipids and Autotaxin |
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