Immune senescence in aged nonhuman primates
Aging is accompanied by a general dysregulation in immune system function, commonly referred to as ‘immune senescence’. This progressive deterioration affects both innate and adaptive immunity, although accumulating evidence indicates that the adaptive arm of the immune system may exhibit more profo...
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| Veröffentlicht in: | Experimental gerontology 2010-09, Vol.45 (9), p.655-661 |
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| container_end_page | 661 |
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| container_issue | 9 |
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| container_title | Experimental gerontology |
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| creator | Haberthur, Kristen Engelman, Flora Barron, Alex Messaoudi, Ilhem |
| description | Aging is accompanied by a general dysregulation in immune system function, commonly referred to as ‘immune senescence’. This progressive deterioration affects both innate and adaptive immunity, although accumulating evidence indicates that the adaptive arm of the immune system may exhibit more profound changes. Most of our current understanding of immune senescence stems from clinical and rodent studies. More recently, the use of nonhuman primates (NHPs) to investigate immune senescence and test interventions aimed at delaying/reversing age-related changes in immune function has dramatically increased. These studies have been greatly facilitated by several key advances in our understanding of the immune system of old world monkeys, specifically the rhesus macaques. In this review we describe the hallmarks of immune senescence in this species and compare them to those described in humans. We also discuss the impact of immune senescence on the response to vaccination and the efficacy of immuno-restorative interventions investigated in this model system. |
| doi_str_mv | 10.1016/j.exger.2010.06.001 |
| format | Article |
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This progressive deterioration affects both innate and adaptive immunity, although accumulating evidence indicates that the adaptive arm of the immune system may exhibit more profound changes. Most of our current understanding of immune senescence stems from clinical and rodent studies. More recently, the use of nonhuman primates (NHPs) to investigate immune senescence and test interventions aimed at delaying/reversing age-related changes in immune function has dramatically increased. These studies have been greatly facilitated by several key advances in our understanding of the immune system of old world monkeys, specifically the rhesus macaques. In this review we describe the hallmarks of immune senescence in this species and compare them to those described in humans. We also discuss the impact of immune senescence on the response to vaccination and the efficacy of immuno-restorative interventions investigated in this model system.</description><subject>Aging</subject><subject>Aging - immunology</subject><subject>Animals</subject><subject>Cercopithecidae - growth & development</subject><subject>Cercopithecidae - immunology</subject><subject>Energy Intake</subject><subject>Fibroblast Growth Factor 7 - physiology</subject><subject>Humans</subject><subject>Immune senescence</subject><subject>Immune System - growth & development</subject><subject>Immune System - physiology</subject><subject>Inflammation - immunology</subject><subject>Inflammation - veterinary</subject><subject>Interleukin-7 - therapeutic use</subject><subject>Macaca mulatta</subject><subject>Macaca mulatta - growth & development</subject><subject>Macaca mulatta - immunology</subject><subject>Primates</subject><subject>Primates - growth & development</subject><subject>Primates - immunology</subject><subject>rejuvenation</subject><subject>Rejuvenation - physiology</subject><subject>T cells</subject><subject>Thymosin - physiology</subject><issn>0531-5565</issn><issn>1873-6815</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctOwzAQtBAIyuMLkFBuHFDK2o4d5wASqnhUqsSld8t1tq2rxoE4qeDvcR9UcIGTpfXM7MwOIZcU-hSovF308WOGTZ9BnIDsA9AD0qMq56lUVBySHghOUyGkOCGnISwAQDJOj8kJAyEUU6pHboZV1XlMAnoMFr3FxPnEzLBMfO3nXWV88ta4yrQYzsnR1CwDXuzeMzJ-ehwPXtLR6_Nw8DBKbVZAmyooRM6ZnMA0kzzLUSlFyyJjGZhMGsGLjMtJSVFayYUVBqQtpDK2KDlwys_I_Vb2rZtUWEZTbWOWeuOi-dS1cfr3j3dzPatXmhUs5uNR4Hon0NTvHYZWVy5mWy6Nx7oLWuUZzVXOin-ReQwEMYSISL5F2qYOocHp3g8Fva5DL_SmDr2uQ4PUsY7IuvoZZc_5vn8E3G0BGO-5cpEerFu3ULoGbavL2v254AthMJsq</recordid><startdate>20100901</startdate><enddate>20100901</enddate><creator>Haberthur, Kristen</creator><creator>Engelman, Flora</creator><creator>Barron, Alex</creator><creator>Messaoudi, Ilhem</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100901</creationdate><title>Immune senescence in aged nonhuman primates</title><author>Haberthur, Kristen ; 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| ispartof | Experimental gerontology, 2010-09, Vol.45 (9), p.655-661 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aging Aging - immunology Animals Cercopithecidae - growth & development Cercopithecidae - immunology Energy Intake Fibroblast Growth Factor 7 - physiology Humans Immune senescence Immune System - growth & development Immune System - physiology Inflammation - immunology Inflammation - veterinary Interleukin-7 - therapeutic use Macaca mulatta Macaca mulatta - growth & development Macaca mulatta - immunology Primates Primates - growth & development Primates - immunology rejuvenation Rejuvenation - physiology T cells Thymosin - physiology |
| title | Immune senescence in aged nonhuman primates |
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