Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation
HLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases. However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined. To determine the effects of HLXL on antigen-s...
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| Veröffentlicht in: | Journal of ethnopharmacology 2009-05, Vol.123 (1), p.40-44 |
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| creator | Rajaiah, Rajesh Lee, David Y.-W. Ma, Zhongze Fan, Arthur Y. Lao, Lixing Fong, Harry H.S. Berman, Brian M. Moudgil, Kamal D. |
| description | HLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases. However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined.
To determine the effects of HLXL on antigen-specific immune parameters in adjuvant-induced inflammation model in the Lewis rat.
Rats were fed daily with either HLXL (2.3
g/kg) or vehicle (water) beginning 3 days before subcutaneous injection of heat-killed
Mycobacterium tuberculosis H37Ra (Mtb), and then continued for another 6 days. After 9 days of Mtb injection, the draining lymph node cells were tested for T cell proliferative and cytokine responses against mycobacterial heat-shock protein 65 (Bhsp65). Moreover, sera were tested for anti-Bhsp65 antibodies and nitric oxide (NO).
HLXL-treated rats showed reduced T cell proliferative response to Bhsp65 compared to control rats. Furthermore, HLXL suppressed IL-17 response but enhanced IL-10 response without much effect on IFN-γ. HLXL treatment also reduced the levels of anti-Bhsp65 antibodies but not that of NO.
HLXL feeding modulated both the cellular and the humoral immune response to Bhsp65 favoring an anti-inflammatory milieu for the suppression of adjuvant-induced inflammation. |
| doi_str_mv | 10.1016/j.jep.2009.02.032 |
| format | Article |
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To determine the effects of HLXL on antigen-specific immune parameters in adjuvant-induced inflammation model in the Lewis rat.
Rats were fed daily with either HLXL (2.3
g/kg) or vehicle (water) beginning 3 days before subcutaneous injection of heat-killed
Mycobacterium tuberculosis H37Ra (Mtb), and then continued for another 6 days. After 9 days of Mtb injection, the draining lymph node cells were tested for T cell proliferative and cytokine responses against mycobacterial heat-shock protein 65 (Bhsp65). Moreover, sera were tested for anti-Bhsp65 antibodies and nitric oxide (NO).
HLXL-treated rats showed reduced T cell proliferative response to Bhsp65 compared to control rats. Furthermore, HLXL suppressed IL-17 response but enhanced IL-10 response without much effect on IFN-γ. HLXL treatment also reduced the levels of anti-Bhsp65 antibodies but not that of NO.
HLXL feeding modulated both the cellular and the humoral immune response to Bhsp65 favoring an anti-inflammatory milieu for the suppression of adjuvant-induced inflammation.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2009.02.032</identifier><identifier>PMID: 19429337</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>animal models ; Animals ; anti-inflammatory activity ; anti-inflammatory agents ; Antibodies ; Antibody Formation ; antigens ; Antigens - immunology ; Biological and medical sciences ; cell-mediated immunity ; Cytokines ; Cytokines - metabolism ; Disease Models, Animal ; drug adjuvants ; General pharmacology ; heat shock proteins ; herbal medicines ; humoral immunity ; Huo-Luo-Xiao-Ling Dan ; Immune modulation ; immune response ; Inflammation ; Inflammation - chemically induced ; Inflammation - immunology ; Inflammation - therapy ; Inflammation Mediators - metabolism ; interferons ; interleukins ; lymphocyte proliferation ; Male ; Medical sciences ; Medicine, Chinese Traditional ; Mycobacterium tuberculosis ; nitric oxide ; Oriental traditional medicine ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Lew ; T cells ; T-lymphocytes ; vaccination</subject><ispartof>Journal of ethnopharmacology, 2009-05, Vol.123 (1), p.40-44</ispartof><rights>2009 Elsevier Ireland Ltd</rights><rights>2009 INIST-CNRS</rights><rights>2009 Elsevier Ireland Ltd. All rights reserved. 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-730caa5cc76d9ec73dba72211071fca92c22b711a3dcbf1111629198ea54c0123</citedby><cites>FETCH-LOGICAL-c565t-730caa5cc76d9ec73dba72211071fca92c22b711a3dcbf1111629198ea54c0123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jep.2009.02.032$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21465294$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19429337$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajaiah, Rajesh</creatorcontrib><creatorcontrib>Lee, David Y.-W.</creatorcontrib><creatorcontrib>Ma, Zhongze</creatorcontrib><creatorcontrib>Fan, Arthur Y.</creatorcontrib><creatorcontrib>Lao, Lixing</creatorcontrib><creatorcontrib>Fong, Harry H.S.</creatorcontrib><creatorcontrib>Berman, Brian M.</creatorcontrib><creatorcontrib>Moudgil, Kamal D.</creatorcontrib><title>Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>HLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases. However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined.
To determine the effects of HLXL on antigen-specific immune parameters in adjuvant-induced inflammation model in the Lewis rat.
Rats were fed daily with either HLXL (2.3
g/kg) or vehicle (water) beginning 3 days before subcutaneous injection of heat-killed
Mycobacterium tuberculosis H37Ra (Mtb), and then continued for another 6 days. After 9 days of Mtb injection, the draining lymph node cells were tested for T cell proliferative and cytokine responses against mycobacterial heat-shock protein 65 (Bhsp65). Moreover, sera were tested for anti-Bhsp65 antibodies and nitric oxide (NO).
HLXL-treated rats showed reduced T cell proliferative response to Bhsp65 compared to control rats. Furthermore, HLXL suppressed IL-17 response but enhanced IL-10 response without much effect on IFN-γ. HLXL treatment also reduced the levels of anti-Bhsp65 antibodies but not that of NO.
HLXL feeding modulated both the cellular and the humoral immune response to Bhsp65 favoring an anti-inflammatory milieu for the suppression of adjuvant-induced inflammation.</description><subject>animal models</subject><subject>Animals</subject><subject>anti-inflammatory activity</subject><subject>anti-inflammatory agents</subject><subject>Antibodies</subject><subject>Antibody Formation</subject><subject>antigens</subject><subject>Antigens - immunology</subject><subject>Biological and medical sciences</subject><subject>cell-mediated immunity</subject><subject>Cytokines</subject><subject>Cytokines - metabolism</subject><subject>Disease Models, Animal</subject><subject>drug adjuvants</subject><subject>General pharmacology</subject><subject>heat shock proteins</subject><subject>herbal medicines</subject><subject>humoral immunity</subject><subject>Huo-Luo-Xiao-Ling Dan</subject><subject>Immune modulation</subject><subject>immune response</subject><subject>Inflammation</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - immunology</subject><subject>Inflammation - therapy</subject><subject>Inflammation Mediators - metabolism</subject><subject>interferons</subject><subject>interleukins</subject><subject>lymphocyte proliferation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine, Chinese Traditional</subject><subject>Mycobacterium tuberculosis</subject><subject>nitric oxide</subject><subject>Oriental traditional medicine</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>T cells</subject><subject>T-lymphocytes</subject><subject>vaccination</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV2L1DAUhoMo7rj6A7zR3uhda85J20wRFmT9WGHAC13wLpxJ0jFDm4xJO-C_N2OHVW_EQEggT07enIexp8Ar4NC-2ld7e6iQ867iWHGB99gK1hJL2Uhxn624kOtyLWu4YI9S2nPOJdT8IbuArsZOCLlidDOHcpPnV0d54_yueEu-GIOZB5psKshPbmd9aVy0erKmcOM4e1tEmw7BJ1s4X5DZz8cMls6bWZ8Y3w80jjS54B-zBz0NyT45r5fs9v27L9c35ebTh4_XbzalbtpmKqXgmqjRWrams1oKsyWJCJAz95o61IhbCUDC6G0PebTYQbe21NSaA4pLdrXUPczb0Rpt_RRpUIfoRoo_VCCn_j7x7pvahaPCDhvoIBd4eS4Qw_fZpkmNLmk7DORtmJNCntvaNPV_ge0SCRZQx5BStP1dGuDqZFDtVTaoTgYVR5UN5jvP_vzG7xtnZRl4cQYoaRr6SF67dMch1G2D3Snl84XrKSjaxczcfkYOIr-LubFtJl4vhM1ajs5GlbSzPgv85VqZ4P4R9CeEssOy</recordid><startdate>20090504</startdate><enddate>20090504</enddate><creator>Rajaiah, Rajesh</creator><creator>Lee, David Y.-W.</creator><creator>Ma, Zhongze</creator><creator>Fan, Arthur Y.</creator><creator>Lao, Lixing</creator><creator>Fong, Harry H.S.</creator><creator>Berman, Brian M.</creator><creator>Moudgil, Kamal D.</creator><general>Elsevier Ireland Ltd</general><general>Amsterdam; New York: Elsevier</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20090504</creationdate><title>Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation</title><author>Rajaiah, Rajesh ; Lee, David Y.-W. ; Ma, Zhongze ; Fan, Arthur Y. ; Lao, Lixing ; Fong, Harry H.S. ; Berman, Brian M. ; Moudgil, Kamal D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-730caa5cc76d9ec73dba72211071fca92c22b711a3dcbf1111629198ea54c0123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>animal models</topic><topic>Animals</topic><topic>anti-inflammatory activity</topic><topic>anti-inflammatory agents</topic><topic>Antibodies</topic><topic>Antibody Formation</topic><topic>antigens</topic><topic>Antigens - immunology</topic><topic>Biological and medical sciences</topic><topic>cell-mediated immunity</topic><topic>Cytokines</topic><topic>Cytokines - metabolism</topic><topic>Disease Models, Animal</topic><topic>drug adjuvants</topic><topic>General pharmacology</topic><topic>heat shock proteins</topic><topic>herbal medicines</topic><topic>humoral immunity</topic><topic>Huo-Luo-Xiao-Ling Dan</topic><topic>Immune modulation</topic><topic>immune response</topic><topic>Inflammation</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - immunology</topic><topic>Inflammation - therapy</topic><topic>Inflammation Mediators - metabolism</topic><topic>interferons</topic><topic>interleukins</topic><topic>lymphocyte proliferation</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine, Chinese Traditional</topic><topic>Mycobacterium tuberculosis</topic><topic>nitric oxide</topic><topic>Oriental traditional medicine</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>T cells</topic><topic>T-lymphocytes</topic><topic>vaccination</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajaiah, Rajesh</creatorcontrib><creatorcontrib>Lee, David Y.-W.</creatorcontrib><creatorcontrib>Ma, Zhongze</creatorcontrib><creatorcontrib>Fan, Arthur Y.</creatorcontrib><creatorcontrib>Lao, Lixing</creatorcontrib><creatorcontrib>Fong, Harry H.S.</creatorcontrib><creatorcontrib>Berman, Brian M.</creatorcontrib><creatorcontrib>Moudgil, Kamal D.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajaiah, Rajesh</au><au>Lee, David Y.-W.</au><au>Ma, Zhongze</au><au>Fan, Arthur Y.</au><au>Lao, Lixing</au><au>Fong, Harry H.S.</au><au>Berman, Brian M.</au><au>Moudgil, Kamal D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2009-05-04</date><risdate>2009</risdate><volume>123</volume><issue>1</issue><spage>40</spage><epage>44</epage><pages>40-44</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>HLXL is a traditional Chinese medicine that has long been used in folk medicine for the treatment of chronic inflammatory diseases. However, the precise immunological mechanisms by which HLXL mediates its anti-inflammatory activity are not fully defined.
To determine the effects of HLXL on antigen-specific immune parameters in adjuvant-induced inflammation model in the Lewis rat.
Rats were fed daily with either HLXL (2.3
g/kg) or vehicle (water) beginning 3 days before subcutaneous injection of heat-killed
Mycobacterium tuberculosis H37Ra (Mtb), and then continued for another 6 days. After 9 days of Mtb injection, the draining lymph node cells were tested for T cell proliferative and cytokine responses against mycobacterial heat-shock protein 65 (Bhsp65). Moreover, sera were tested for anti-Bhsp65 antibodies and nitric oxide (NO).
HLXL-treated rats showed reduced T cell proliferative response to Bhsp65 compared to control rats. Furthermore, HLXL suppressed IL-17 response but enhanced IL-10 response without much effect on IFN-γ. HLXL treatment also reduced the levels of anti-Bhsp65 antibodies but not that of NO.
HLXL feeding modulated both the cellular and the humoral immune response to Bhsp65 favoring an anti-inflammatory milieu for the suppression of adjuvant-induced inflammation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>19429337</pmid><doi>10.1016/j.jep.2009.02.032</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2009-05, Vol.123 (1), p.40-44 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2925191 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | animal models Animals anti-inflammatory activity anti-inflammatory agents Antibodies Antibody Formation antigens Antigens - immunology Biological and medical sciences cell-mediated immunity Cytokines Cytokines - metabolism Disease Models, Animal drug adjuvants General pharmacology heat shock proteins herbal medicines humoral immunity Huo-Luo-Xiao-Ling Dan Immune modulation immune response Inflammation Inflammation - chemically induced Inflammation - immunology Inflammation - therapy Inflammation Mediators - metabolism interferons interleukins lymphocyte proliferation Male Medical sciences Medicine, Chinese Traditional Mycobacterium tuberculosis nitric oxide Oriental traditional medicine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Rats Rats, Inbred Lew T cells T-lymphocytes vaccination |
| title | Huo-Luo-Xiao-Ling Dan modulates antigen-directed immune response in adjuvant-induced inflammation |
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