Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity
Abstract Aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. However, no study has determined if GDNF protects dopaminergic neurons via inhibiting nitric oxide generation in Parkinson'...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroimmunology 2010-08, Vol.225 (1), p.43-51 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 51 |
|---|---|
| container_issue | 1 |
| container_start_page | 43 |
| container_title | Journal of neuroimmunology |
| container_volume | 225 |
| creator | Xing, Bin Xin, Tao Zhao, Lingling Hunter, Randy L Chen, Yan Bing, Guoying |
| description | Abstract Aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. However, no study has determined if GDNF protects dopaminergic neurons via inhibiting nitric oxide generation in Parkinson's disease animal model. We report that GDNF not only reduces lipopolysaccharide-induced degeneration of dopaminergic neurons, suppresses microglia activation and nitric oxide generation, but also reverses the inhibition of phosphoinositide 3-kinase (PI3K) in dopaminergic neurons and microglia. It suggests that the neuroprotective effect of GDNF on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of PI3K in both neurons and microglia. |
| doi_str_mv | 10.1016/j.jneuroim.2010.04.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2924924</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165572810001700</els_id><sourcerecordid>815533006</sourcerecordid><originalsourceid>FETCH-LOGICAL-c557t-3a42dc929fef8f9bc64de83822f058da3dd0db588a0da95e640cf45d6d9e5aa93</originalsourceid><addsrcrecordid>eNqFUsFu1DAQtRAVXQq_UOXGKYvt2IlzqUAVLUiVOBTO1qw92XVI4mAnK1b9eZzutgIuSJaeNPPeG2veEHLJ6JpRVr5v1-2Ac_CuX3OailSsE7wgK6YqnivB2UuySkSZy4qrc_I6xpZSJgtRvyLnnIqKlbVakYfbzkGXGey6rHMD5haD26PNHt2n4MedM1kDZvIhG1MFzRSz3tlNADdk1o_QJ1nYJtajZIgZbFMrTslv9KPvDhGM2UFwFk-u_pczbjq8IWcNdBHfnvCCfL_59O36c3739fbL9ce73EhZTXkBgltT87rBRjX1xpTCoioU5w2VykJhLbUbqRRQC7XEUlDTCGlLW6MEqIsLcnX0HedNj9bgMAXo9BhcD-GgPTj9d2dwO731e81rLtJLBu9OBsH_nDFOundxWRkM6OeoFZOyKCgtE7M8Mk3wMQZsnqcwqpfgdKufgtNLcJoKnSAJL__847PsKalE-HAkYNrU3mHQ0TgcDFoXUibaevf_GVf_WJgUuTPQ_cADxtbPYUg5aKYj11TfL-ezXA-j6XIqSovfFzfI1Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>815533006</pqid></control><display><type>article</type><title>Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Xing, Bin ; Xin, Tao ; Zhao, Lingling ; Hunter, Randy L ; Chen, Yan ; Bing, Guoying</creator><creatorcontrib>Xing, Bin ; Xin, Tao ; Zhao, Lingling ; Hunter, Randy L ; Chen, Yan ; Bing, Guoying</creatorcontrib><description>Abstract Aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. However, no study has determined if GDNF protects dopaminergic neurons via inhibiting nitric oxide generation in Parkinson's disease animal model. We report that GDNF not only reduces lipopolysaccharide-induced degeneration of dopaminergic neurons, suppresses microglia activation and nitric oxide generation, but also reverses the inhibition of phosphoinositide 3-kinase (PI3K) in dopaminergic neurons and microglia. It suggests that the neuroprotective effect of GDNF on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of PI3K in both neurons and microglia.</description><identifier>ISSN: 0165-5728</identifier><identifier>EISSN: 1872-8421</identifier><identifier>DOI: 10.1016/j.jneuroim.2010.04.010</identifier><identifier>PMID: 20471698</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>1-Phosphatidylinositol 3-kinase ; Allergy and Immunology ; Animals ; Animals, Newborn ; Cells, Cultured ; Dopamine - metabolism ; Dopaminergic neurons ; Dose-Response Relationship, Drug ; Drug Interactions ; Embryo, Mammalian ; GDNF ; Glial Cell Line-Derived Neurotrophic Factors - pharmacology ; Lipopolysaccharides - toxicity ; Mesencephalon - cytology ; Microglia ; Microglia - drug effects ; Microglia - physiology ; Neurology ; Neurons - drug effects ; Nitric oxide ; Nitric Oxide - metabolism ; Organ Culture Techniques ; Parkinson's disease ; Phosphatidylinositol 3-Kinases - metabolism ; PI3K ; Rats ; Rats, Sprague-Dawley ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>Journal of neuroimmunology, 2010-08, Vol.225 (1), p.43-51</ispartof><rights>Elsevier B.V.</rights><rights>2010 Elsevier B.V.</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><rights>2010 Elsevier B.V. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-3a42dc929fef8f9bc64de83822f058da3dd0db588a0da95e640cf45d6d9e5aa93</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jneuroim.2010.04.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20471698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xing, Bin</creatorcontrib><creatorcontrib>Xin, Tao</creatorcontrib><creatorcontrib>Zhao, Lingling</creatorcontrib><creatorcontrib>Hunter, Randy L</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Bing, Guoying</creatorcontrib><title>Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity</title><title>Journal of neuroimmunology</title><addtitle>J Neuroimmunol</addtitle><description>Abstract Aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. However, no study has determined if GDNF protects dopaminergic neurons via inhibiting nitric oxide generation in Parkinson's disease animal model. We report that GDNF not only reduces lipopolysaccharide-induced degeneration of dopaminergic neurons, suppresses microglia activation and nitric oxide generation, but also reverses the inhibition of phosphoinositide 3-kinase (PI3K) in dopaminergic neurons and microglia. It suggests that the neuroprotective effect of GDNF on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of PI3K in both neurons and microglia.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Cells, Cultured</subject><subject>Dopamine - metabolism</subject><subject>Dopaminergic neurons</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Interactions</subject><subject>Embryo, Mammalian</subject><subject>GDNF</subject><subject>Glial Cell Line-Derived Neurotrophic Factors - pharmacology</subject><subject>Lipopolysaccharides - toxicity</subject><subject>Mesencephalon - cytology</subject><subject>Microglia</subject><subject>Microglia - drug effects</subject><subject>Microglia - physiology</subject><subject>Neurology</subject><subject>Neurons - drug effects</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Organ Culture Techniques</subject><subject>Parkinson's disease</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>PI3K</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>0165-5728</issn><issn>1872-8421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsFu1DAQtRAVXQq_UOXGKYvt2IlzqUAVLUiVOBTO1qw92XVI4mAnK1b9eZzutgIuSJaeNPPeG2veEHLJ6JpRVr5v1-2Ac_CuX3OailSsE7wgK6YqnivB2UuySkSZy4qrc_I6xpZSJgtRvyLnnIqKlbVakYfbzkGXGey6rHMD5haD26PNHt2n4MedM1kDZvIhG1MFzRSz3tlNADdk1o_QJ1nYJtajZIgZbFMrTslv9KPvDhGM2UFwFk-u_pczbjq8IWcNdBHfnvCCfL_59O36c3739fbL9ce73EhZTXkBgltT87rBRjX1xpTCoioU5w2VykJhLbUbqRRQC7XEUlDTCGlLW6MEqIsLcnX0HedNj9bgMAXo9BhcD-GgPTj9d2dwO731e81rLtJLBu9OBsH_nDFOundxWRkM6OeoFZOyKCgtE7M8Mk3wMQZsnqcwqpfgdKufgtNLcJoKnSAJL__847PsKalE-HAkYNrU3mHQ0TgcDFoXUibaevf_GVf_WJgUuTPQ_cADxtbPYUg5aKYj11TfL-ezXA-j6XIqSovfFzfI1Q</recordid><startdate>20100825</startdate><enddate>20100825</enddate><creator>Xing, Bin</creator><creator>Xin, Tao</creator><creator>Zhao, Lingling</creator><creator>Hunter, Randy L</creator><creator>Chen, Yan</creator><creator>Bing, Guoying</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100825</creationdate><title>Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity</title><author>Xing, Bin ; Xin, Tao ; Zhao, Lingling ; Hunter, Randy L ; Chen, Yan ; Bing, Guoying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c557t-3a42dc929fef8f9bc64de83822f058da3dd0db588a0da95e640cf45d6d9e5aa93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Cells, Cultured</topic><topic>Dopamine - metabolism</topic><topic>Dopaminergic neurons</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Interactions</topic><topic>Embryo, Mammalian</topic><topic>GDNF</topic><topic>Glial Cell Line-Derived Neurotrophic Factors - pharmacology</topic><topic>Lipopolysaccharides - toxicity</topic><topic>Mesencephalon - cytology</topic><topic>Microglia</topic><topic>Microglia - drug effects</topic><topic>Microglia - physiology</topic><topic>Neurology</topic><topic>Neurons - drug effects</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Organ Culture Techniques</topic><topic>Parkinson's disease</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>PI3K</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xing, Bin</creatorcontrib><creatorcontrib>Xin, Tao</creatorcontrib><creatorcontrib>Zhao, Lingling</creatorcontrib><creatorcontrib>Hunter, Randy L</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Bing, Guoying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of neuroimmunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xing, Bin</au><au>Xin, Tao</au><au>Zhao, Lingling</au><au>Hunter, Randy L</au><au>Chen, Yan</au><au>Bing, Guoying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity</atitle><jtitle>Journal of neuroimmunology</jtitle><addtitle>J Neuroimmunol</addtitle><date>2010-08-25</date><risdate>2010</risdate><volume>225</volume><issue>1</issue><spage>43</spage><epage>51</epage><pages>43-51</pages><issn>0165-5728</issn><eissn>1872-8421</eissn><abstract>Abstract Aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. However, no study has determined if GDNF protects dopaminergic neurons via inhibiting nitric oxide generation in Parkinson's disease animal model. We report that GDNF not only reduces lipopolysaccharide-induced degeneration of dopaminergic neurons, suppresses microglia activation and nitric oxide generation, but also reverses the inhibition of phosphoinositide 3-kinase (PI3K) in dopaminergic neurons and microglia. It suggests that the neuroprotective effect of GDNF on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of PI3K in both neurons and microglia.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20471698</pmid><doi>10.1016/j.jneuroim.2010.04.010</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-5728 |
| ispartof | Journal of neuroimmunology, 2010-08, Vol.225 (1), p.43-51 |
| issn | 0165-5728 1872-8421 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2924924 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 1-Phosphatidylinositol 3-kinase Allergy and Immunology Animals Animals, Newborn Cells, Cultured Dopamine - metabolism Dopaminergic neurons Dose-Response Relationship, Drug Drug Interactions Embryo, Mammalian GDNF Glial Cell Line-Derived Neurotrophic Factors - pharmacology Lipopolysaccharides - toxicity Mesencephalon - cytology Microglia Microglia - drug effects Microglia - physiology Neurology Neurons - drug effects Nitric oxide Nitric Oxide - metabolism Organ Culture Techniques Parkinson's disease Phosphatidylinositol 3-Kinases - metabolism PI3K Rats Rats, Sprague-Dawley Tyrosine 3-Monooxygenase - metabolism |
| title | Glial cell line-derived neurotrophic factor protects midbrain dopaminergic neurons against lipopolysaccharide neurotoxicity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T06%3A46%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glial%20cell%20line-derived%20neurotrophic%20factor%20protects%20midbrain%20dopaminergic%20neurons%20against%20lipopolysaccharide%20neurotoxicity&rft.jtitle=Journal%20of%20neuroimmunology&rft.au=Xing,%20Bin&rft.date=2010-08-25&rft.volume=225&rft.issue=1&rft.spage=43&rft.epage=51&rft.pages=43-51&rft.issn=0165-5728&rft.eissn=1872-8421&rft_id=info:doi/10.1016/j.jneuroim.2010.04.010&rft_dat=%3Cproquest_pubme%3E815533006%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=815533006&rft_id=info:pmid/20471698&rft_els_id=S0165572810001700&rfr_iscdi=true |