Visualizing canonical Wnt signaling during mouse craniofacial development
Wnt signaling is critical for proper development of the head and face in the mouse embryo, playing important roles in various aspects of craniofacial development ranging from axis formation to survival of cranial neural crest cells to patterning of the brain. The signaling requirements for the devel...
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| Veröffentlicht in: | Developmental dynamics 2010-01, Vol.239 (1), p.354-363 |
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| container_title | Developmental dynamics |
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| creator | Mani, Preethi Jarrell, Andrew Myers, John Atit, Radhika |
| description | Wnt signaling is critical for proper development of the head and face in the mouse embryo, playing important roles in various aspects of craniofacial development ranging from axis formation to survival of cranial neural crest cells to patterning of the brain. The signaling requirements for the development of different cell lineages in the head and face are active areas of investigation. In this study, we use a recently developed TCF/Lef‐LacZ transgenic reporter mouse to characterize the expression of canonical Wnt signaling activity during craniofacial development. We present an atlas of representative sections to show embryonic craniofacial development. Our results demonstrate a pattern of sustained Wnt signaling reporter activity in most tissues which suggests sequential roles in craniofacial development. Developmental Dynamics 239:354–363, 2010. © 2009 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/dvdy.22072 |
| format | Article |
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| ispartof | Developmental dynamics, 2010-01, Vol.239 (1), p.354-363 |
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| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals beta-Galactosidase Crosses, Genetic embryo Genotype Head - anatomy & histology Head - embryology Histological Techniques - methods Mice Mice, Transgenic mouse sections Signal Transduction - physiology TCF/Lef‐LacZ transgene Wnt Proteins - metabolism |
| title | Visualizing canonical Wnt signaling during mouse craniofacial development |
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