A Clinic-Based Lifestyle Intervention for Pediatric Obesity: Efficacy and Behavioral and Biochemical Predictors of Response
To examine efficacy and predictors of response to a lifestyle intervention for obese youth. Retrospective chart review of 214 children and adolescents aged 8-19 years. Linear regression identified baseline predictors of response (delta BMI z-score) at first and ultimate follow-up visits. Mean delta...
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| Veröffentlicht in: | Journal of Pediatric Endocrinology and Metabolism 2009-09, Vol.22 (9), p.805-814 |
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| container_title | Journal of Pediatric Endocrinology and Metabolism |
| container_volume | 22 |
| creator | Madsen, K.A. Garber, A.K. Mietus-Snyder, M.L. Orrell-Valente, J.K. Tran, C.-T. Wlasiuk, L. Matos, R.I. Neuhaus, J. Lustig, R.H. |
| description | To examine efficacy and predictors of response to a lifestyle intervention for obese youth.
Retrospective chart review of 214 children and adolescents aged 8-19 years. Linear regression identified baseline predictors of response (delta BMI z-score) at first and ultimate follow-up visits.
Mean delta BMI z-score from baseline was -0.04 (p < 0.001) at first follow-up and -0.09 (p < 0.001) at ultimate follow-up (median time 10 mo) among 156 children and adolescents. Higher baseline BMI z-score predicted poor response at first and ultimate follow-up, explaining 10% of variance in response. Fasting insulin explained 6% of response variance at first follow-up. delta BMI z-score at the first visit along with baseline BMI z-score explained up to 50% of variance in response at ultimate visit.
Clinic-based interventions improve weight status. Baseline variables predict only a small proportion of response; response at the first visit is a more meaningful tool to guide clinical decisions. |
| doi_str_mv | 10.1515/JPEM.2009.22.9.805 |
| format | Article |
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Retrospective chart review of 214 children and adolescents aged 8-19 years. Linear regression identified baseline predictors of response (delta BMI z-score) at first and ultimate follow-up visits.
Mean delta BMI z-score from baseline was -0.04 (p < 0.001) at first follow-up and -0.09 (p < 0.001) at ultimate follow-up (median time 10 mo) among 156 children and adolescents. Higher baseline BMI z-score predicted poor response at first and ultimate follow-up, explaining 10% of variance in response. Fasting insulin explained 6% of response variance at first follow-up. delta BMI z-score at the first visit along with baseline BMI z-score explained up to 50% of variance in response at ultimate visit.
Clinic-based interventions improve weight status. Baseline variables predict only a small proportion of response; response at the first visit is a more meaningful tool to guide clinical decisions.</description><identifier>ISSN: 0334-018X</identifier><identifier>EISSN: 2191-0251</identifier><identifier>DOI: 10.1515/JPEM.2009.22.9.805</identifier><identifier>PMID: 19960890</identifier><language>eng</language><publisher>Germany: De Gruyter</publisher><subject>Adolescent ; Adolescent Behavior - physiology ; Adult ; Ambulatory Care ; Behavior Therapy - methods ; Biomarkers - analysis ; Biomarkers - blood ; Child ; Diet Therapy ; Female ; Follow-Up Studies ; Humans ; Male ; Motor Activity ; Obesity - blood ; Obesity - diagnosis ; Obesity - psychology ; Obesity - therapy ; Prognosis ; Retrospective Studies ; Risk Reduction Behavior ; Television ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of Pediatric Endocrinology and Metabolism, 2009-09, Vol.22 (9), p.805-814</ispartof><rights>Freund Publishing House Ltd., London</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-bf1312b0a9d61f6928cd2c06252a9ebda6891afe53d6f55af822d250f7145b143</citedby><cites>FETCH-LOGICAL-c439t-bf1312b0a9d61f6928cd2c06252a9ebda6891afe53d6f55af822d250f7145b143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,782,786,887,27931,27932</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19960890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Madsen, K.A.</creatorcontrib><creatorcontrib>Garber, A.K.</creatorcontrib><creatorcontrib>Mietus-Snyder, M.L.</creatorcontrib><creatorcontrib>Orrell-Valente, J.K.</creatorcontrib><creatorcontrib>Tran, C.-T.</creatorcontrib><creatorcontrib>Wlasiuk, L.</creatorcontrib><creatorcontrib>Matos, R.I.</creatorcontrib><creatorcontrib>Neuhaus, J.</creatorcontrib><creatorcontrib>Lustig, R.H.</creatorcontrib><title>A Clinic-Based Lifestyle Intervention for Pediatric Obesity: Efficacy and Behavioral and Biochemical Predictors of Response</title><title>Journal of Pediatric Endocrinology and Metabolism</title><addtitle>J Pediatr Endocrinol Metab</addtitle><description>To examine efficacy and predictors of response to a lifestyle intervention for obese youth.
Retrospective chart review of 214 children and adolescents aged 8-19 years. Linear regression identified baseline predictors of response (delta BMI z-score) at first and ultimate follow-up visits.
Mean delta BMI z-score from baseline was -0.04 (p < 0.001) at first follow-up and -0.09 (p < 0.001) at ultimate follow-up (median time 10 mo) among 156 children and adolescents. Higher baseline BMI z-score predicted poor response at first and ultimate follow-up, explaining 10% of variance in response. Fasting insulin explained 6% of response variance at first follow-up. delta BMI z-score at the first visit along with baseline BMI z-score explained up to 50% of variance in response at ultimate visit.
Clinic-based interventions improve weight status. Baseline variables predict only a small proportion of response; response at the first visit is a more meaningful tool to guide clinical decisions.</description><subject>Adolescent</subject><subject>Adolescent Behavior - physiology</subject><subject>Adult</subject><subject>Ambulatory Care</subject><subject>Behavior Therapy - methods</subject><subject>Biomarkers - analysis</subject><subject>Biomarkers - blood</subject><subject>Child</subject><subject>Diet Therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Motor Activity</subject><subject>Obesity - blood</subject><subject>Obesity - diagnosis</subject><subject>Obesity - psychology</subject><subject>Obesity - therapy</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Reduction Behavior</subject><subject>Television</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0334-018X</issn><issn>2191-0251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUV1v0zAUtRCIVWN_gAfkN54Sru04iXlAWqvCNnVbQWPqm-U4NjWkcWenFdX-_Fy12uDpyjof9_gehN4TyAkn_NPVfHqdUwCRU5qLvAb-Co0oESQDyslrNALGigxIvThBZzH-BgAChBHO3qITIkQJtYARejzHk871TmdjFU2LZ86aOOw6gy_7wYSt6Qfne2x9wHPTOjUEp_FtY6Ibdp_x1Fqnld5h1bd4bJZq63xQ3eHpvF6aVcI7PA9JqwcfIvYW_zBx7fto3qE3VnXRnB3nKfr5dXo3uchmt98uJ-ezTBdMDFljU2zagBJtSWwpaK1bqqGknCphmlaVtSDKGs7a0nKubE1pSznYihS8IQU7RV8OvutNszKtTn9KIeU6uJUKO-mVk_8jvVvKX34rqUgHZVUy-Hg0CP5hk-4jVy5q03WqN34TZcVYCQxYnZj0wNTBxxiMfd5CQO57k_ve5L43SakUMvWWRB_-zfciObaUCNmB4OJg_j7jKvyRZcUqLr_fFfJmcb8Y3zMmb9gTwYSlSQ</recordid><startdate>20090901</startdate><enddate>20090901</enddate><creator>Madsen, K.A.</creator><creator>Garber, A.K.</creator><creator>Mietus-Snyder, M.L.</creator><creator>Orrell-Valente, J.K.</creator><creator>Tran, C.-T.</creator><creator>Wlasiuk, L.</creator><creator>Matos, R.I.</creator><creator>Neuhaus, J.</creator><creator>Lustig, R.H.</creator><general>De Gruyter</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20090901</creationdate><title>A Clinic-Based Lifestyle Intervention for Pediatric Obesity: Efficacy and Behavioral and Biochemical Predictors of Response</title><author>Madsen, K.A. ; Garber, A.K. ; Mietus-Snyder, M.L. ; Orrell-Valente, J.K. ; Tran, C.-T. ; Wlasiuk, L. ; Matos, R.I. ; Neuhaus, J. ; Lustig, R.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-bf1312b0a9d61f6928cd2c06252a9ebda6891afe53d6f55af822d250f7145b143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adolescent Behavior - physiology</topic><topic>Adult</topic><topic>Ambulatory Care</topic><topic>Behavior Therapy - methods</topic><topic>Biomarkers - analysis</topic><topic>Biomarkers - blood</topic><topic>Child</topic><topic>Diet Therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Motor Activity</topic><topic>Obesity - blood</topic><topic>Obesity - diagnosis</topic><topic>Obesity - psychology</topic><topic>Obesity - therapy</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Reduction Behavior</topic><topic>Television</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Madsen, K.A.</creatorcontrib><creatorcontrib>Garber, A.K.</creatorcontrib><creatorcontrib>Mietus-Snyder, M.L.</creatorcontrib><creatorcontrib>Orrell-Valente, J.K.</creatorcontrib><creatorcontrib>Tran, C.-T.</creatorcontrib><creatorcontrib>Wlasiuk, L.</creatorcontrib><creatorcontrib>Matos, R.I.</creatorcontrib><creatorcontrib>Neuhaus, J.</creatorcontrib><creatorcontrib>Lustig, R.H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Pediatric Endocrinology and Metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Madsen, K.A.</au><au>Garber, A.K.</au><au>Mietus-Snyder, M.L.</au><au>Orrell-Valente, J.K.</au><au>Tran, C.-T.</au><au>Wlasiuk, L.</au><au>Matos, R.I.</au><au>Neuhaus, J.</au><au>Lustig, R.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Clinic-Based Lifestyle Intervention for Pediatric Obesity: Efficacy and Behavioral and Biochemical Predictors of Response</atitle><jtitle>Journal of Pediatric Endocrinology and Metabolism</jtitle><addtitle>J Pediatr Endocrinol Metab</addtitle><date>2009-09-01</date><risdate>2009</risdate><volume>22</volume><issue>9</issue><spage>805</spage><epage>814</epage><pages>805-814</pages><issn>0334-018X</issn><eissn>2191-0251</eissn><abstract>To examine efficacy and predictors of response to a lifestyle intervention for obese youth.
Retrospective chart review of 214 children and adolescents aged 8-19 years. Linear regression identified baseline predictors of response (delta BMI z-score) at first and ultimate follow-up visits.
Mean delta BMI z-score from baseline was -0.04 (p < 0.001) at first follow-up and -0.09 (p < 0.001) at ultimate follow-up (median time 10 mo) among 156 children and adolescents. Higher baseline BMI z-score predicted poor response at first and ultimate follow-up, explaining 10% of variance in response. Fasting insulin explained 6% of response variance at first follow-up. delta BMI z-score at the first visit along with baseline BMI z-score explained up to 50% of variance in response at ultimate visit.
Clinic-based interventions improve weight status. Baseline variables predict only a small proportion of response; response at the first visit is a more meaningful tool to guide clinical decisions.</abstract><cop>Germany</cop><pub>De Gruyter</pub><pmid>19960890</pmid><doi>10.1515/JPEM.2009.22.9.805</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Pediatric Endocrinology and Metabolism, 2009-09, Vol.22 (9), p.805-814 |
| issn | 0334-018X 2191-0251 |
| language | eng |
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| source | MEDLINE; De Gruyter journals |
| subjects | Adolescent Adolescent Behavior - physiology Adult Ambulatory Care Behavior Therapy - methods Biomarkers - analysis Biomarkers - blood Child Diet Therapy Female Follow-Up Studies Humans Male Motor Activity Obesity - blood Obesity - diagnosis Obesity - psychology Obesity - therapy Prognosis Retrospective Studies Risk Reduction Behavior Television Treatment Outcome Young Adult |
| title | A Clinic-Based Lifestyle Intervention for Pediatric Obesity: Efficacy and Behavioral and Biochemical Predictors of Response |
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