Modification of the cardiovascular effects of L-dopa by decarboxylase inhibitors

Intravenously infused L-dopa (0.3 mg/kg per min) produced hypertension and cardiac arrhythmias in halothane anesthetized dogs. Biochemical studies showed that the heart, kidney, and brain of these animals accumulated significant amounts of catecholamines formed from the administered precursor. Pretr...

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Veröffentlicht in:	The Journal of clinical investigation 1971-06, Vol.50 (6), p.1322-1328
Hauptverfasser:	Watanabe, A M, Parks, L C, Kopin, I J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta - physiology Aromatic Amino Acid Decarboxylase Inhibitors Arrhythmias, Cardiac - chemically induced Blood Pressure - drug effects Brain - metabolism Catecholamines - biosynthesis Dihydroxyphenylalanine - antagonists & inhibitors Dihydroxyphenylalanine - metabolism Dogs Drug Antagonism Electric Stimulation Hindlimb Hydrazines - pharmacology Hypertension - chemically induced Kidney - metabolism Myocardium - metabolism Perfusion Stereoisomerism Vascular Resistance - drug effects
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