A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia

The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation. In the mouse, Gfi1 deficiency causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome. We report here that a variant allele of GFI1 (GFI136...

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Veröffentlicht in:	Blood 2010-03, Vol.115 (12), p.2462-2472
Hauptverfasser:	Khandanpour, Cyrus, Thiede, Christian, Valk, Peter J.M., Sharif-Askari, Ehssan, Nückel, Holger, Lohmann, Dietmar, Horsthemke, Bernhard, Siffert, Winfried, Neubauer, Andreas, Grzeschik, Karl-Heinz, Bloomfield, Clara D., Marcucci, Guido, Maharry, Kati, Slovak, Marilyn L., van der Reijden, Bert A., Jansen, Joop H., Schackert, Hans K., Afshar, Khashayar, Schnittger, Susanne, Peeters, Justine K., Kroschinsky, Frank, Ehninger, Gerhard, Lowenberg, Bob, Dührsen, Ulrich, Möröy, Tarik
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Biological and medical sciences Cell Nucleus - metabolism Chlorocebus aethiops Core Binding Factor Alpha 2 Subunit - metabolism COS Cells DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Female Gene Frequency Genetic Predisposition to Disease Genetic Variation HeLa Cells Hematologic and hematopoietic diseases Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Linkage Disequilibrium Male Medical sciences Mice Middle Aged Myeloid Neoplasia NIH 3T3 Cells Oncogene Proteins, Fusion - metabolism Polymorphism, Single Nucleotide RUNX1 Translocation Partner 1 Protein Transcription Factors - genetics Transcription Factors - metabolism Translocation, Genetic Young Adult
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