Synthesis and evaluation of 4-quinazolinone compounds as potential antimalarial agents

Febrifugine is an alkaloid isolated from Dichroa febrifuga as the active component against Plasmodium falciparum. Adverse side effects have precluded febrifugine as a potential clinical drug. As part of an ongoing malaria chemotherapy project, novel febrifugine analogues were designed and synthesize...

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Veröffentlicht in:	European journal of medicinal chemistry 2010-09, Vol.45 (9), p.3864-3869
Hauptverfasser:	Zhu, Shuren, Wang, Joe, Chandrashekar, Gudise, Smith, Erika, Liu, Xianjun, Zhang, Yongshen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Antimalarials - toxicity Antiparasitic agents Biological and medical sciences Cell Line Drug design Drug Evaluation, Preclinical Febrifugine Malaria chemotherapy Medical sciences Mice Mice, Inbred ICR Pharmacology. Drug treatments Plasmodium falciparum Plasmodium falciparum - drug effects Quinazolinones - chemical synthesis Quinazolinones - chemistry Quinazolinones - pharmacology Quinazolinones - toxicity
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