The marine sponge metabolite mycothiazole: A novel prototype mitochondrial complex I inhibitor

A natural product chemistry-based approach was applied to discover small-molecule inhibitors of hypoxia-inducible factor-1 (HIF-1). A Petrosaspongia mycofijiensis marine sponge extract yielded mycothiazole ( 1), a solid tumor selective compound with no known mechanism for its cell line-dependent cyt...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2010-08, Vol.18 (16), p.5988-5994
Hauptverfasser:	Morgan, J. Brian, Mahdi, Fakhri, Liu, Yang, Coothankandaswamy, Veena, Jekabsons, Mika B., Johnson, Tyler A., Sashidhara, Koneni V., Crews, Phillip, Nagle, Dale G., Zhou, Yu-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell Line, Tumor Cell Survival - drug effects Cells, Cultured Electron Transport Complex I - antagonists & inhibitors Electron Transport Complex I - metabolism Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Female Gene Expression Regulation - drug effects General pharmacology Humans Hypoxia-Inducible Factor 1 - antagonists & inhibitors Hypoxia-Inducible Factor 1 - genetics Hypoxia-Inducible Factor 1 - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor-1 (HIF-1) Marine natural products Medical sciences Mitochondrial complex I inhibitor NADH-ubiquinone oxidoreductase Neovascularization, Pathologic - drug therapy Neurons - drug effects Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Porifera - chemistry Rats Thiazoles - isolation & purification Thiazoles - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!