Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites

Five resveratrol sulfate metabolites were synthesized and assessed for activities known to be mediated by resveratrol: inhibition of tumor necrosis factor (TNF) α induced NFκB activity, cylcooxygenases (COX-1 and COX-2), aromatase, nitric oxide production in endotoxin-stimulated macrophages, prolife...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-07, Vol.53 (13), p.5033-5043
Hauptverfasser:	Hoshino, Juma, Park, Eun-Jung, Kondratyuk, Tamara P, Marler, Laura, Pezzuto, John M, van Breemen, Richard B, Mo, Shunyan, Li, Yongchao, Cushman, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Aromatase - metabolism Biphenyl Compounds - antagonists & inhibitors Biphenyl Compounds - metabolism Cell Survival - drug effects Cyclooxygenase 1 - metabolism Cyclooxygenase 2 - metabolism Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology HL-60 Cells Humans Inhibitory Concentration 50 Macrophages - drug effects Macrophages - metabolism Magnetic Resonance Spectroscopy Mice NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors NAD(P)H Dehydrogenase (Quinone) - metabolism NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - metabolism Picrates - antagonists & inhibitors Picrates - metabolism Spectrometry, Mass, Electrospray Ionization Spectroscopy, Fourier Transform Infrared Stilbenes - chemistry Stilbenes - metabolism Stilbenes - pharmacology Sulfuric Acid Esters - chemical synthesis Sulfuric Acid Esters - chemistry Sulfuric Acid Esters - pharmacology
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