The identification of chromosomal translocation, t(4;6)(q22;q15), in prostate cancer

Our previous work identified a chromosomal translocation t(4;6) in prostate cancer cell lines and primary tumors. Using probes located on 4q22 and 6q15, the breakpoints identified in LNCaP cells, we performed fluorescence in situ hybridization analysis to detect this translocation in a large series...

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Veröffentlicht in:	Prostate cancer and prostatic diseases 2010-06, Vol.13 (2), p.117-125
Hauptverfasser:	Shan, L, Ambroisine, L, Clark, J, Yáñez-Muñoz, R J, Fisher, G, Kudahetti, S C, Yang, J, Kia, S, Mao, X, Fletcher, A, Flohr, P, Edwards, S, Attard, G, De-Bono, J, Young, B D, Foster, C S, Reuter, V, Moller, H, Oliver, T D, Berney, D M, Scardino, P, Cuzick, J, Cooper, C S, Lu, Y-J
Format:	Artikel
Sprache:	eng
Schlagworte:	692/420/2489/1381/1853 692/699/67/589/466 Biomedical and Life Sciences Biomedicine Breakpoints Cancer Research Chromosome translocations Chromosomes, Human, Pair 4 - genetics Chromosomes, Human, Pair 6 - genetics DNA probes Fluorescence Fluorescence in situ hybridization Fusion protein Genetic aspects Genomic Instability Humans Hybridization analysis In Situ Hybridization, Fluorescence Male Oncogene Proteins, Fusion - genetics original-article Prognosis Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Risk factors Statistical analysis Statistical methods Translocation Translocation (Genetics) Translocation, Genetic Tumor cell lines Tumors
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