Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer

Mammalian forkhead members of the class O (FOXO) transcription factors, including FOXO1, FOXO3a, and FOXO4, are implicated in the regulation of several biological processes, including the stress resistance, metabolism, cell cycle, apoptosis and DNA repair. The objectives of this study were to examin...

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Veröffentlicht in:	Journal of molecular signaling 2010-07, Vol.5 (1), p.10-10
Hauptverfasser:	Roy, Sanjit K, Srivastava, Rakesh K, Shankar, Sharmila
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell cycle Genetic aspects Pancreatic cancer Physiological aspects Protein kinases Risk factors Transcription factors
Online-Zugang:	Volltext
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