Oral Administration of High Molecular Weight Hyaluronan (900 kDa) Controls Immune System via Toll-like Receptor 4 in the Intestinal Epithelium

Low molecular weight hyaluronan enhances or induces inflammation through toll-like receptor 4 (TLR-4).However, the effects of high molecular weight hyaluronan (HA900) on TLR-4 are unknown. In this study, HA900 (900 kDa) was administered orally to MRL-lpr/lpr mice, a Th-1-type autoimmune disease mode...

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Veröffentlicht in:	The Journal of biological chemistry 2010-08, Vol.285 (32), p.24751-24758
Hauptverfasser:	Asari, Akira, Kanemitsu, Tomoyuki, Kurihara, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Cell Death Female Gene Expression Regulation Glycobiology and Extracellular Matrices Humans Hyaluronate Hyaluronic Acid - administration & dosage Hyaluronic Acid - chemistry Immune System Immunology Inflammation Intestinal Mucosa - cytology Mice Mice, Transgenic Oligonucleotide Array Sequence Analysis Pleiotrophin Suppressor of Cytokine Signaling 3 Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - metabolism Toll-Like Receptor 4 - metabolism Toll-like Receptors (TLR)
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