Recipient Tissue Factor Expression Is Associated With Consumptive Coagulopathy in Pig‐to‐Primate Kidney Xenotransplantation

Consumptive coagulopathy (CC) remains a challenge in pig‐to‐primate organ xenotransplantation (Tx). This study investigated the role of tissue factor (TF) expression on circulating platelets and peripheral blood mononuclear cells (PBMCs). Baboons (n = 9) received a kidney graft from pigs that were e...

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Veröffentlicht in:	American journal of transplantation 2010-07, Vol.10 (7), p.1556-1568
Hauptverfasser:	Lin, C. C., Ezzelarab, M., Shapiro, R., Ekser, B., Long, C., Hara, H., Echeverri, G., Torres, C., Watanabe, H., Ayares, D., Dorling, A., Cooper, D. K. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - therapeutic use Antilymphocyte Serum - therapeutic use Baboon Biological and medical sciences CD40 Ligand - immunology coagulation Disseminated Intravascular Coagulation - pathology Famotidine - therapeutic use Galactosyltransferases - genetics Gene Knockout Techniques Graft Rejection - pathology Histamine H2 Antagonists - therapeutic use Immunosuppressive Agents - therapeutic use Kidney Transplantation - adverse effects Medical sciences Papio Papio - immunology PBMC pig Platelet Activation Platelet Aggregation platelets Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Swine Thrombin - biosynthesis Thromboplastin - genetics tissue factor Transplantation, Heterologous - adverse effects xenotransplantation
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