Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188

In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules (cisplatin, bleomycin, or p...

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Veröffentlicht in:BioMed research international 2010-01, Vol.2010 (2010), p.1-11
Hauptverfasser: Tsoneva, Iana, Iordanov, Iordan, Berger, Annette J., Tomov, Toma, Nikolova, Biliana, Mudrov, Nikola, Berger, Martin R.
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container_end_page 11
container_issue 2010
container_start_page 1
container_title BioMed research international
container_volume 2010
creator Tsoneva, Iana
Iordanov, Iordan
Berger, Annette J.
Tomov, Toma
Nikolova, Biliana
Mudrov, Nikola
Berger, Martin R.
description In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules (cisplatin, bleomycin, or propidium iodide) can pass/diffuse. It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures. The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability. Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase. The volume of tumors stopped to grow after electrochemotherapy and the use of poloxamer 188 reduced the edema near the electrode and around the subcutaneously growing tumors.
doi_str_mv 10.1155/2010/314213
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It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures. The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability. Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase. The volume of tumors stopped to grow after electrochemotherapy and the use of poloxamer 188 reduced the edema near the electrode and around the subcutaneously growing tumors.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2010/314213</identifier><identifier>PMID: 20706647</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Antineoplastic Agents - pharmacokinetics ; Biological and medical sciences ; Biotechnology ; Bleomycin - pharmacokinetics ; Brushes ; Cancer ; Cancer therapies ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival ; Cisplatin - pharmacokinetics ; Delay ; Drug Delivery Systems - methods ; Electrodes ; Electroporation ; Electroporation - methods ; Flow Cytometry ; Free radicals ; Genes ; HeLa Cells ; Hemolysis - drug effects ; Humans ; Hydrophobic and Hydrophilic Interactions ; Iodides ; Jurkat Cells ; Luciferases - genetics ; Luciferases - metabolism ; Luminescent Proteins - genetics ; Luminescent Proteins - metabolism ; Medical sciences ; Membranes ; Mice ; Mice, Nude ; Molecular weight ; Pharmacology. 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It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures. The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability. Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase. 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subjects Animals
Antineoplastic Agents - pharmacokinetics
Biological and medical sciences
Biotechnology
Bleomycin - pharmacokinetics
Brushes
Cancer
Cancer therapies
Cell Line, Tumor
Cell Proliferation - drug effects
Cell Survival
Cisplatin - pharmacokinetics
Delay
Drug Delivery Systems - methods
Electrodes
Electroporation
Electroporation - methods
Flow Cytometry
Free radicals
Genes
HeLa Cells
Hemolysis - drug effects
Humans
Hydrophobic and Hydrophilic Interactions
Iodides
Jurkat Cells
Luciferases - genetics
Luciferases - metabolism
Luminescent Proteins - genetics
Luminescent Proteins - metabolism
Medical sciences
Membranes
Mice
Mice, Nude
Molecular weight
Pharmacology. Drug treatments
Poloxamer - administration & dosage
Porosity
Porosity - drug effects
Propidium
Red Fluorescent Protein
Spectrometry, Fluorescence
Surfactants
Tumors
Whole Body Imaging
Xenograft Model Antitumor Assays
title Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188
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