Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188
In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules (cisplatin, bleomycin, or p...
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description | In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules (cisplatin, bleomycin, or propidium iodide) can pass/diffuse. It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures. The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability. Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase. The volume of tumors stopped to grow after electrochemotherapy and the use of poloxamer 188 reduced the edema near the electrode and around the subcutaneously growing tumors. |
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It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures. The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability. Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase. The volume of tumors stopped to grow after electrochemotherapy and the use of poloxamer 188 reduced the edema near the electrode and around the subcutaneously growing tumors.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2010/314213</identifier><identifier>PMID: 20706647</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Animals ; Antineoplastic Agents - pharmacokinetics ; Biological and medical sciences ; Biotechnology ; Bleomycin - pharmacokinetics ; Brushes ; Cancer ; Cancer therapies ; Cell Line, Tumor ; Cell Proliferation - drug effects ; Cell Survival ; Cisplatin - pharmacokinetics ; Delay ; Drug Delivery Systems - methods ; Electrodes ; Electroporation ; Electroporation - methods ; Flow Cytometry ; Free radicals ; Genes ; HeLa Cells ; Hemolysis - drug effects ; Humans ; Hydrophobic and Hydrophilic Interactions ; Iodides ; Jurkat Cells ; Luciferases - genetics ; Luciferases - metabolism ; Luminescent Proteins - genetics ; Luminescent Proteins - metabolism ; Medical sciences ; Membranes ; Mice ; Mice, Nude ; Molecular weight ; Pharmacology. Drug treatments ; Poloxamer - administration & dosage ; Porosity ; Porosity - drug effects ; Propidium ; Red Fluorescent Protein ; Spectrometry, Fluorescence ; Surfactants ; Tumors ; Whole Body Imaging ; Xenograft Model Antitumor Assays</subject><ispartof>BioMed research international, 2010-01, Vol.2010 (2010), p.1-11</ispartof><rights>Copyright © 2010</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Iana Tsoneva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2010 Iana Tsoneva et al. 2010 Copyright © 2010 Iana Tsoneva et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-b81fda6c8a57453e9548e1b330004c90dd4575bf236a6c94b718ce802ecc8f893</citedby><cites>FETCH-LOGICAL-c559t-b81fda6c8a57453e9548e1b330004c90dd4575bf236a6c94b718ce802ecc8f893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913842/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2913842/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25876477$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20706647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Takao, Sonshin</contributor><creatorcontrib>Tsoneva, Iana</creatorcontrib><creatorcontrib>Iordanov, Iordan</creatorcontrib><creatorcontrib>Berger, Annette J.</creatorcontrib><creatorcontrib>Tomov, Toma</creatorcontrib><creatorcontrib>Nikolova, Biliana</creatorcontrib><creatorcontrib>Mudrov, Nikola</creatorcontrib><creatorcontrib>Berger, Martin R.</creatorcontrib><title>Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>In the present study it is shown that poloxamer 188, added before or immediately after an electrical pulse used for electroporation, decreases the number of dead cells and at the same time does not reduce the number of reversible electropores through which small molecules (cisplatin, bleomycin, or propidium iodide) can pass/diffuse. It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures. The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability. Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase. The volume of tumors stopped to grow after electrochemotherapy and the use of poloxamer 188 reduced the edema near the electrode and around the subcutaneously growing tumors.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Bleomycin - pharmacokinetics</subject><subject>Brushes</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation - drug effects</subject><subject>Cell Survival</subject><subject>Cisplatin - pharmacokinetics</subject><subject>Delay</subject><subject>Drug Delivery Systems - methods</subject><subject>Electrodes</subject><subject>Electroporation</subject><subject>Electroporation - methods</subject><subject>Flow Cytometry</subject><subject>Free radicals</subject><subject>Genes</subject><subject>HeLa Cells</subject><subject>Hemolysis - drug effects</subject><subject>Humans</subject><subject>Hydrophobic and Hydrophilic Interactions</subject><subject>Iodides</subject><subject>Jurkat Cells</subject><subject>Luciferases - genetics</subject><subject>Luciferases - metabolism</subject><subject>Luminescent Proteins - genetics</subject><subject>Luminescent Proteins - metabolism</subject><subject>Medical sciences</subject><subject>Membranes</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Molecular weight</subject><subject>Pharmacology. Drug treatments</subject><subject>Poloxamer - administration & dosage</subject><subject>Porosity</subject><subject>Porosity - drug effects</subject><subject>Propidium</subject><subject>Red Fluorescent Protein</subject><subject>Spectrometry, Fluorescence</subject><subject>Surfactants</subject><subject>Tumors</subject><subject>Whole Body Imaging</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1110-7243</issn><issn>2314-6133</issn><issn>1110-7251</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqF0Utv1DAUBWALgWgprFiDIiRURDXU1-9skKppgYpKdAFry3FuOqkycWsnhf77Os0wPBawsuV8Or7OIeQ50HcAUh4yCvSQg2DAH5BdAKALzSQ83O4F3yFPUrqkFLRR5WOyw6imSgm9Sz6fdOiHGGrs2huMt0VoiuM4XqSi7YdQLF3vMRZL7LrppBhWWJxHTJiPJ3oeuvDDrTMBY56SR43rEj7brHvk24eTr8tPi7MvH0-XR2cLL2U5LCoDTe2UN05qITmWUhiEinNKqfAlrWshtawaxlVWpag0GI-GMvTeNKbke-T9nHs1VmusPfZDdJ29iu3axVsbXGv__NK3K3sRbiwrgRvBcsD-JiCG6xHTYNdt8vmNrscwJmukVEblgbJ8808JSgNnUt6HvvqLXoYx9vlH5DyVob4f_WBGPoaUIjbbqYHaqU07tWnnNrN--ftDt_ZnfRm83gCXvOuamOtq0y8njc5scm9nt2r72n1v_3PrixljJti4LRaK5Xv5HRfSu1Q</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Tsoneva, Iana</creator><creator>Iordanov, Iordan</creator><creator>Berger, Annette J.</creator><creator>Tomov, Toma</creator><creator>Nikolova, Biliana</creator><creator>Mudrov, Nikola</creator><creator>Berger, Martin R.</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>Dar al -Nasr -al-Llktruni</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7U5</scope><scope>F28</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20100101</creationdate><title>Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188</title><author>Tsoneva, Iana ; Iordanov, Iordan ; Berger, Annette J. ; Tomov, Toma ; Nikolova, Biliana ; Mudrov, Nikola ; Berger, Martin R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-b81fda6c8a57453e9548e1b330004c90dd4575bf236a6c94b718ce802ecc8f893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Biological and medical sciences</topic><topic>Biotechnology</topic><topic>Bleomycin - pharmacokinetics</topic><topic>Brushes</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation - drug effects</topic><topic>Cell Survival</topic><topic>Cisplatin - pharmacokinetics</topic><topic>Delay</topic><topic>Drug Delivery Systems - methods</topic><topic>Electrodes</topic><topic>Electroporation</topic><topic>Electroporation - methods</topic><topic>Flow Cytometry</topic><topic>Free radicals</topic><topic>Genes</topic><topic>HeLa Cells</topic><topic>Hemolysis - drug effects</topic><topic>Humans</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>Iodides</topic><topic>Jurkat Cells</topic><topic>Luciferases - genetics</topic><topic>Luciferases - metabolism</topic><topic>Luminescent Proteins - genetics</topic><topic>Luminescent Proteins - metabolism</topic><topic>Medical sciences</topic><topic>Membranes</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Molecular weight</topic><topic>Pharmacology. 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It was suggested that hydrophobic sections of poloxamer 188 molecules are incorporated into the edges of pores and that their hydrophilic parts act as brushy pore structures. The formation of brushy pores may reduce the expansion of pores and delay the irreversible electropermeability. Tumors were implanted subcutaneously in both flanks of nude mice using HeLa cells, transfected with genes for red fluorescent protein and luciferase. The volume of tumors stopped to grow after electrochemotherapy and the use of poloxamer 188 reduced the edema near the electrode and around the subcutaneously growing tumors.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>20706647</pmid><doi>10.1155/2010/314213</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Animals Antineoplastic Agents - pharmacokinetics Biological and medical sciences Biotechnology Bleomycin - pharmacokinetics Brushes Cancer Cancer therapies Cell Line, Tumor Cell Proliferation - drug effects Cell Survival Cisplatin - pharmacokinetics Delay Drug Delivery Systems - methods Electrodes Electroporation Electroporation - methods Flow Cytometry Free radicals Genes HeLa Cells Hemolysis - drug effects Humans Hydrophobic and Hydrophilic Interactions Iodides Jurkat Cells Luciferases - genetics Luciferases - metabolism Luminescent Proteins - genetics Luminescent Proteins - metabolism Medical sciences Membranes Mice Mice, Nude Molecular weight Pharmacology. Drug treatments Poloxamer - administration & dosage Porosity Porosity - drug effects Propidium Red Fluorescent Protein Spectrometry, Fluorescence Surfactants Tumors Whole Body Imaging Xenograft Model Antitumor Assays |
title | Electrodelivery of Drugs into Cancer Cells in the Presence of Poloxamer 188 |
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