TGFβ1 induces Jagged1 expression in astrocytes via ALK5 and Smad3 and regulates the balance between oligodendrocyte progenitor proliferation and differentiation

Notch1 receptor signaling regulates oligodendrocyte progenitor differentiation and myelin formation in development, and during remyelination in the adult CNS. In active multiple sclerosis lesions, Notch1 localizes to oligodendrocyte lineage cells, and its ligand Jagged1 is expressed by reactive astr...

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Veröffentlicht in:	Glia 2010-06, Vol.58 (8), p.964-974
Hauptverfasser:	Zhang, Yueting, Zhang, Jingya, Navrazhina, Kristina, Argaw, Azeb Tadesse, Zameer, Andleeb, Gurfein, Blake T., Brosnan, Celia F., John, Gareth R.
Format:	Artikel
Sprache:	eng
Schlagworte:	autoimmunity CNS repair multiple sclerosis Notch
Online-Zugang:	Volltext
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