Nucleophile activation in PD…(D/E)xK metallonucleases: An experimental and computational pKa study

Metallonucleases conduct metal dependent nucleic acid hydrolysis. While metal ions serve in multiple mechanistic capacities in these enzymes, precisely how the attacking water is activated remains unclear for those lacking an obvious general base. All arguments hinge on appropriate pK a ’s for activ...

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Veröffentlicht in:	Journal of inorganic biochemistry 2010-06, Vol.104 (6), p.665-672
Hauptverfasser:	Xie, Fuqian, Briggs, James M., Dupureur, Cynthia M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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