HIV-associated nephropathy: role of mammalian target of rapamycin pathway

Both glomerular and tubular lesions are characterized by a proliferative phenotype in HIV-associated nephropathy. We hypothesized that mammalian target of rapamycin (mTOR) contributes to the development of the HIVAN phenotype. Both glomerular and tubular epithelial cells showed enhanced expression o...

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Veröffentlicht in:	The American journal of pathology 2010-08, Vol.177 (2), p.813-821
Hauptverfasser:	Kumar, Dileep, Konkimalla, Sridevi, Yadav, Anju, Sataranatarajan, Kavithalakshmi, Kasinath, Balakuntalam S, Chander, Praveen N, Singhal, Pravin C
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS-Associated Nephropathy - metabolism AIDS-Associated Nephropathy - pathology Animals Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Kidney Glomerulus - cytology Kidney Tubules - cytology Male Mice Mice, Transgenic Phenotype Regular Ribosomal Protein S6 Kinases, 70-kDa - genetics Ribosomal Protein S6 Kinases, 70-kDa - metabolism Signal Transduction - physiology TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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