A Gene Expression Signature that Can Predict the Recurrence of Tamoxifen-Treated Primary Breast Cancer

Purpose: The identification of a molecular signature predicting the relapse of tamoxifen-treated primary breast cancers should help the therapeutic management of estrogen receptor–positive cancers. Experimental Design: A series of 132 primary tumors from patients who received adjuvant tamoxifen were...

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Veröffentlicht in:	Clinical cancer research 2008-03, Vol.14 (6), p.1744-1752
Hauptverfasser:	CHANRION, Maïa, NEGRE, Vincent, DARBON, Jean-Marie, FONTAINE, Hélène, SALVETAT, Nicolas, BIBEAU, Frederic, GROGAN, Gaëtan Mac, MAURIAC, Louis, KATSAROS, Dionyssios, MOLINA, Franck, THEILLET, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antineoplastic agents Antineoplastic Agents, Hormonal - therapeutic use Biochemistry, Molecular Biology Biological and medical sciences breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Breast Neoplasms - genetics Cancer Carcinoma - diagnosis Carcinoma - drug therapy Carcinoma - genetics Chemotherapy, Adjuvant classifier Cluster Analysis Disease-Free Survival Drug Resistance, Neoplasm - genetics Female Follow-Up Studies Gene Expression Profiling Genomics Gynecology. Andrology. Obstetrics Humans Life Sciences Mammary gland diseases Medical sciences Middle Aged Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - genetics Oligonucleotide Array Sequence Analysis Pharmacology. Drug treatments Prognosis Receptors, Estrogen - genetics Receptors, Progesterone - genetics Sensitivity and Specificity tamoxifen Tamoxifen - therapeutic use Treatment Outcome Tumors
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