Lack of effects of typical and atypical antipsychotics in DARPP-32 and NCS-1 levels in PC12 cells overexpressing NCS-1

Schizophrenia is the major psychiatry disorder, which the exact cause remains unknown. However, it is well known that dopamine-mediated neurotransmission imbalance is associated with this pathology and the main target of antipsychotics is the dopamine receptor D2. Recently, it was described alterati...

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Veröffentlicht in:	Journal of negative results in biomedicine 2010-06, Vol.9 (1), p.4-4, Article 4
Hauptverfasser:	Souza, Bruno R, Torres, Karen C L, Miranda, Débora M, Motta, Bernardo S, Scotti-Muzzi, Estêvão, Guimarães, Melissa M, Carneiro, Daniel S, Rosa, Daniela V F, Souza, Renan P, Reis, Helton J, Jeromin, Andreas, Romano-Silva, Marco A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Blotting, Western Clone Cells Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Neuronal Calcium-Sensor Proteins - metabolism Neuropeptides - metabolism PC12 Cells Rats
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