Organ-specific roles of CYP1A1 during detoxication of dietary benzo[a]pyrene

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental toxicants derived from sources that include cigarette smoke, petroleum distillation, gas- and diesel-engine exhaust, and charcoal-grilled food. The gastrointestinal tract is the principal route of PAH exposures, even when i...

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Veröffentlicht in:	Molecular pharmacology 2010-07, Vol.78 (1), p.46-57
Hauptverfasser:	Shi, Zhanquan, Dragin, Nadine, Gálvez-Peralta, Marina, Jorge-Nebert, Lucia F, Miller, Marian L, Wang, Bin, Nebert, Daniel W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence Benzo(a)pyrene - administration & dosage Benzo(a)pyrene - pharmacokinetics Benzo(a)pyrene - pharmacology Body Weight - drug effects Cytochrome P-450 CYP1A1 - genetics Cytochrome P-450 CYP1A1 - metabolism Diet DNA Primers Inactivation, Metabolic Male Mice Mice, Inbred C57BL Mice, Knockout Organ Size - drug effects RNA, Messenger - genetics
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