Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells

Polycomb Repressive Complex 2 (PRC2) regulates key developmental genes in embryonic stem (ES) cells and during development. Here we show that Jarid2/Jumonji, a protein enriched in pluripotent cells and a founding member of the Jumonji C (JmjC) domain protein family, is a PRC2 subunit in ES cells. Ge...

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Veröffentlicht in:	Cell 2009-12, Vol.139 (7), p.1290-1302
Hauptverfasser:	Peng, Jamy C., Valouev, Anton, Swigut, Tomek, Zhang, Junmei, Zhao, Yingming, Sidow, Arend, Wysocka, Joanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DEVBIO Embryonic Stem Cells - metabolism Freshwater Gene Knockdown Techniques Humans Mice Mitochondria - metabolism Nerve Tissue Proteins - metabolism Polycomb Repressive Complex 2 Polycomb-Group Proteins PROTEINS Repressor Proteins - metabolism Retinoblastoma-Binding Protein 2 - metabolism RNA - metabolism STEMCELL Xenopus laevis
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