The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction

The impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is a temporal correlation between high-mobility group box 1 (HMGB-1), microglial activation, and cognitive dysfunction....

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Veröffentlicht in:	Critical care (London, England) England), 2010-01, Vol.14 (3), p.R88-R88, Article R88
Hauptverfasser:	Terrando, Niccolò, Rei Fidalgo, António, Vizcaychipi, Marcela, Cibelli, Mario, Ma, Daqing, Monaco, Claudia, Feldmann, Marc, Maze, Mervyn
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological markers Cognition disorders Cognition Disorders - chemically induced Cognition Disorders - immunology Cognition Disorders - prevention & control Critical care medicine Cytokines - blood Endotoxemia - chemically induced Endotoxemia - metabolism Escherichia coli Escherichia coli - immunology Escherichia coli - metabolism Genetic aspects Hippocampus - metabolism HMGB1 Protein - metabolism Identification and classification Interleukin-1 Interleukin-1 - antagonists & inhibitors Interleukin-1 - genetics Interleukin-1 - pharmacology Lipopolysaccharides Lipopolysaccharides - administration & dosage Lipopolysaccharides - adverse effects Mice Mice, Inbred C57BL Microglia - metabolism Properties Risk factors Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - drug effects
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