Islet Transplantation in Type 1 Diabetics Using an Immunosuppressive Protocol Based on the Anti‐LFA‐1 Antibody Efalizumab

The applicability of islet transplantation as treatment for type 1 diabetes is limited by renal and islet toxicities of currently available immunosuppressants. We describe a novel immunosuppressive regimen using the antileukocyte functional antigen‐1 antibody efalizumab which permits long‐term islet...

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Veröffentlicht in:	American journal of transplantation 2010-08, Vol.10 (8), p.1870-1880
Hauptverfasser:	Posselt, A. M., Bellin, M. D., Tavakol, M., Szot, G. L., Frassetto, L. A., Masharani, U., Kerlan, R. K., Fong, L., Vincenti, F. G., Hering, B. J., Bluestone, J. A., Stock, P. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal, Humanized Antilymphocyte Serum - therapeutic use Biological and medical sciences Blood Glucose - metabolism Clinical islet transplantation Diabetes Mellitus, Type 1 - surgery Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Fundamental and applied biological sciences. Psychology Fundamental immunology Humans immunoregulatory T lymphocytes immunosuppressant therapy Immunosuppression Therapy - methods Islets of Langerhans Transplantation - methods Lymphocyte Function-Associated Antigen-1 - administration & dosage lymphocyte trafficking Male Medical sciences Middle Aged Mycophenolic Acid - therapeutic use prednisone‐free immunosuppression Sirolimus - therapeutic use Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tacrolimus - administration & dosage Tissue, organ and graft immunology type 1 diabetes mellitus
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