The N Terminus of Cbl-c Regulates Ubiquitin Ligase Activity by Modulating Affinity for the Ubiquitin-conjugating Enzyme

Cbl proteins are ubiquitin ligases (E3s) that play a significant role in regulating tyrosine kinase signaling. There are three mammalian family members: Cbl, Cbl-b, and Cbl-c. All have a highly conserved N-terminal tyrosine kinase binding domain, a catalytic RING finger domain, and a C-terminal prol...

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Veröffentlicht in:	The Journal of biological chemistry 2010-07, Vol.285 (31), p.23687-23698
Hauptverfasser:	Ryan, Philip E., Sivadasan-Nair, Nina, Nau, Marion M., Nicholas, Sarah, Lipkowitz, Stanley
Format:	Artikel
Sprache:	eng
Schlagworte:	Cbl Proteins Cbl-c E3 Ubiquitin Ligase Glutathione Transferase - metabolism Humans Kinetics Mutagenesis, Site-Directed Mutation Phosphorylation Protein Binding Protein Synthesis and Degradation Proto-Oncogene Proteins c-cbl - chemistry Proto-Oncogene Proteins c-cbl - metabolism Recombinant Proteins - chemistry Signal Transduction src Homology Domains Tyrosine-protein Kinase (Tyrosine Kinase) Ubiquitin - chemistry Ubiquitin Ligase Ubiquitin-conjugating Enzyme (Ubc) Ubiquitin-Protein Ligases - chemistry Ubiquitination
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