Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant

dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity. Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn...

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Veröffentlicht in:	BioMed research international 2010-01, Vol.2010 (2010), p.1-17
Hauptverfasser:	Jin, Bo, Sun, Tao, Yu, Xiao-Hong, Liu, Chao-Qun, Yang, Ying-Xiang, Lu, Ping, Fu, Shan-Feng, Qiu, Hui-Bin, Yeo, Anthony E. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - drug effects Adjuvants, Immunologic - pharmacology Animals Apoptosis Cancer Cancer Vaccines - immunology Humans Immune system Immunologic Factors - immunology Kinases Pattern recognition Phosphorylation Proteins Review RNA, Double-Stranded - immunology Signal Transduction - drug effects Signal Transduction - immunology Viral infections
Online-Zugang:	Volltext
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