Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant
dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity. Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn...
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| creator | Jin, Bo Sun, Tao Yu, Xiao-Hong Liu, Chao-Qun Yang, Ying-Xiang Lu, Ping Fu, Shan-Feng Qiu, Hui-Bin Yeo, Anthony E. T. |
| description | dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity. Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn present antigen epitopes with MHC-I molecules to naïve T cells. Coadministration of protein and synthetic dsRNA analogues can elicit an antigen-specific Th1-polarized immune response which stimulates the CD8+ CTL response and possibly dampen Th17 response. Synthetic dsRNA analogues have been tested as vaccine adjuvant against viral infections in animal models. However, a dsRNA receptor, TLR3 can be expressed in tumor cells while other members of TLR family, for example, TLR4 and TLR2 have been shown to promote tumor progression, metastasis, and chemoresistance. Thus, the promising potential of dsRNA analogues as a tumor therapeutic vaccine adjuvant should be evaluated cautiously. |
| doi_str_mv | 10.1155/2010/690438 |
| format | Article |
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T.</creator><contributor>Xiao, Zhengguo</contributor><creatorcontrib>Jin, Bo ; Sun, Tao ; Yu, Xiao-Hong ; Liu, Chao-Qun ; Yang, Ying-Xiang ; Lu, Ping ; Fu, Shan-Feng ; Qiu, Hui-Bin ; Yeo, Anthony E. T. ; Xiao, Zhengguo</creatorcontrib><description>dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity. Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn present antigen epitopes with MHC-I molecules to naïve T cells. Coadministration of protein and synthetic dsRNA analogues can elicit an antigen-specific Th1-polarized immune response which stimulates the CD8+ CTL response and possibly dampen Th17 response. Synthetic dsRNA analogues have been tested as vaccine adjuvant against viral infections in animal models. However, a dsRNA receptor, TLR3 can be expressed in tumor cells while other members of TLR family, for example, TLR4 and TLR2 have been shown to promote tumor progression, metastasis, and chemoresistance. Thus, the promising potential of dsRNA analogues as a tumor therapeutic vaccine adjuvant should be evaluated cautiously.</description><identifier>ISSN: 1110-7243</identifier><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 1110-7251</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2010/690438</identifier><identifier>PMID: 20671921</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Adaptive Immunity - drug effects ; Adjuvants, Immunologic - pharmacology ; Animals ; Apoptosis ; Cancer ; Cancer Vaccines - immunology ; Humans ; Immune system ; Immunologic Factors - immunology ; Kinases ; Pattern recognition ; Phosphorylation ; Proteins ; Review ; RNA, Double-Stranded - immunology ; Signal Transduction - drug effects ; Signal Transduction - immunology ; Viral infections</subject><ispartof>BioMed research international, 2010-01, Vol.2010 (2010), p.1-17</ispartof><rights>Copyright © 2010</rights><rights>Copyright © 2010 Bo Jin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2010 Bo Jin et al. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-c0eb4bd912d32eb322bc8fd8ce0bc86d6136be25715348eaab2b0ececd9fadb83</citedby><cites>FETCH-LOGICAL-c496t-c0eb4bd912d32eb322bc8fd8ce0bc86d6136be25715348eaab2b0ececd9fadb83</cites><orcidid>0000-0002-7907-6029</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910503/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910503/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20671921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Xiao, Zhengguo</contributor><creatorcontrib>Jin, Bo</creatorcontrib><creatorcontrib>Sun, Tao</creatorcontrib><creatorcontrib>Yu, Xiao-Hong</creatorcontrib><creatorcontrib>Liu, Chao-Qun</creatorcontrib><creatorcontrib>Yang, Ying-Xiang</creatorcontrib><creatorcontrib>Lu, Ping</creatorcontrib><creatorcontrib>Fu, Shan-Feng</creatorcontrib><creatorcontrib>Qiu, Hui-Bin</creatorcontrib><creatorcontrib>Yeo, Anthony E. T.</creatorcontrib><title>Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant</title><title>BioMed research international</title><addtitle>J Biomed Biotechnol</addtitle><description>dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity. Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn present antigen epitopes with MHC-I molecules to naïve T cells. Coadministration of protein and synthetic dsRNA analogues can elicit an antigen-specific Th1-polarized immune response which stimulates the CD8+ CTL response and possibly dampen Th17 response. Synthetic dsRNA analogues have been tested as vaccine adjuvant against viral infections in animal models. However, a dsRNA receptor, TLR3 can be expressed in tumor cells while other members of TLR family, for example, TLR4 and TLR2 have been shown to promote tumor progression, metastasis, and chemoresistance. Thus, the promising potential of dsRNA analogues as a tumor therapeutic vaccine adjuvant should be evaluated cautiously.</description><subject>Adaptive Immunity - drug effects</subject><subject>Adjuvants, Immunologic - pharmacology</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cancer Vaccines - immunology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunologic Factors - immunology</subject><subject>Kinases</subject><subject>Pattern recognition</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Review</subject><subject>RNA, Double-Stranded - immunology</subject><subject>Signal Transduction - drug effects</subject><subject>Signal Transduction - immunology</subject><subject>Viral infections</subject><issn>1110-7243</issn><issn>2314-6133</issn><issn>1110-7251</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU1rFTEUhoMo9kNXrpXBjaBcm5NMMslGuJRaLxQVUbchH2fsXGaSdjJT6b9vLlMv6qZkkUPy8OScvIS8APoeQIgTRoGeSE1rrh6RQwCgq4YJeLyva35AjnLeUgqNkvopOWBUNqAZHJLzzTDMMQ0pzL2d0nhbnbUt-ilXqa1C_vZ5XdkYqk05-JomjFNn-8rm6qf1votYrcN2vrFxekaetLbP-Px-PyY_Pp59P_20uvhyvjldX6x8reW08hRd7YIGFjhDxxlzXrVBeaSlkEEClw6ZaEDwWqG1jjmKHn3QrQ1O8WPyYfFezW7A4EtHo-3N1dgNdrw1yXbm35vYXZpf6cYwDVRQXgRv7gVjup4xT2bosse-txHTnI0SQqqy6INkU2sKSusd-fo_cpvmMZZ_KDoJTXlYFOjdAvkx5Txiu28aqNkFaXZBmiXIQr_6e849-ye5ArxdgMsuBvu7e8D2coGxINjaPVxGUIzyO3vyr2M</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Jin, Bo</creator><creator>Sun, Tao</creator><creator>Yu, Xiao-Hong</creator><creator>Liu, Chao-Qun</creator><creator>Yang, Ying-Xiang</creator><creator>Lu, Ping</creator><creator>Fu, Shan-Feng</creator><creator>Qiu, Hui-Bin</creator><creator>Yeo, Anthony E. 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T.</au><au>Xiao, Zhengguo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant</atitle><jtitle>BioMed research international</jtitle><addtitle>J Biomed Biotechnol</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>2010</volume><issue>2010</issue><spage>1</spage><epage>17</epage><pages>1-17</pages><issn>1110-7243</issn><issn>2314-6133</issn><eissn>1110-7251</eissn><eissn>2314-6141</eissn><abstract>dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity. Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn present antigen epitopes with MHC-I molecules to naïve T cells. Coadministration of protein and synthetic dsRNA analogues can elicit an antigen-specific Th1-polarized immune response which stimulates the CD8+ CTL response and possibly dampen Th17 response. Synthetic dsRNA analogues have been tested as vaccine adjuvant against viral infections in animal models. However, a dsRNA receptor, TLR3 can be expressed in tumor cells while other members of TLR family, for example, TLR4 and TLR2 have been shown to promote tumor progression, metastasis, and chemoresistance. Thus, the promising potential of dsRNA analogues as a tumor therapeutic vaccine adjuvant should be evaluated cautiously.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>20671921</pmid><doi>10.1155/2010/690438</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-7907-6029</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptive Immunity - drug effects Adjuvants, Immunologic - pharmacology Animals Apoptosis Cancer Cancer Vaccines - immunology Humans Immune system Immunologic Factors - immunology Kinases Pattern recognition Phosphorylation Proteins Review RNA, Double-Stranded - immunology Signal Transduction - drug effects Signal Transduction - immunology Viral infections |
| title | Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant |
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