Patterns of social-experience-related c- fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development
Recent findings from our laboratory indicate that alterations in frontal cortex function, structural plasticity, and related social behaviors are persistent consequences of exposure to moderate levels of ethanol during prenatal brain development [24]. Fetal-ethanol-related reductions in the expressi...
Gespeichert in:
| Veröffentlicht in: | Behavioural brain research 2010-12, Vol.214 (1), p.66-74 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 74 |
|---|---|
| container_issue | 1 |
| container_start_page | 66 |
| container_title | Behavioural brain research |
| container_volume | 214 |
| creator | Hamilton, Derek A. Candelaria-Cook, Felicha T. Akers, Katherine G. Rice, James P. Maes, Levi I. Rosenberg, Martina Valenzuela, C. Fernando Savage, Daniel D. |
| description | Recent findings from our laboratory indicate that alterations in frontal cortex function, structural plasticity, and related social behaviors are persistent consequences of exposure to moderate levels of ethanol during prenatal brain development
[24]. Fetal-ethanol-related reductions in the expression of the immediate early genes (IEGs) c-
fos and
Arc and alterations in dendritic spine density in ventrolateral and medial aspects of frontal cortex suggest a dissociation reminiscent of that described by Kolb et al.
[38] in which these aspects of frontal cortex undergo reciprocal experience-dependent changes. In addition to providing a brief review of the available data on social behavior and frontal cortex function in fetal-ethanol-exposed rats, the present paper presents novel data on social-experience-related IEG expression in four regions of frontal cortex (Zilles LO, VLO, Fr1, Fr2) that are evaluated alongside our prior data from AID and Cg3. Social experience in normal rats was related to a distinct pattern of IEG expression in ventrolateral and medial aspects of frontal cortex, with generally greater expression observed in ventrolateral frontal cortex. In contrast, weaker expression was observed in all aspects of frontal cortex in ethanol-exposed rats, with the exception of an experience-related increase in the medial agranular cortex. Behaviors related to social investigation and wrestling/boxing were differentially correlated with patterns of activity-related IEG expression in the regions under investigation for saccharin- and ethanol-exposed rats. These observations suggest that recruitment and expression of IEGs in frontal cortex following social experience are potentially important for understanding the long-term consequences of moderate prenatal ethanol exposure on frontal cortex function, synaptic plasticity, and related behaviors. |
| doi_str_mv | 10.1016/j.bbr.2010.05.048 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2910219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166432810004225</els_id><sourcerecordid>815532975</sourcerecordid><originalsourceid>FETCH-LOGICAL-c548t-5f72354c76737742be728729bed5fbcff5e610dcac78df6282910cb0701faae43</originalsourceid><addsrcrecordid>eNp9kc2KFDEURgtRnHb0AdxIdq6qTVKVShWCMAz-wYAudB1Syc10mnTS3qSb8b18QFPd46AbVyHkfOeG-zXNS0bXjLLhzXY9z7jmtN6pWNN-fNSs2Ch5K0U_PW5WlRnavuPjRfMs5y2ltKeCPW0uOBWSDtO4an591aUAxkySIzkZr0MLd3tAD9FAixB0AUtMS1zKREdLrtCQSiDk7FMkPpKyAeIwxaIDMQmLN3DSoS55QVOuhpJI1sZsNNZEQrJLFioAJMARwomHstExBWIPlbkldUTUi3NGXTN24dJ-B7E8b544HTK8uD8vm-8f3n-7_tTefPn4-frqpjWiH0srnOSd6I0cZCdlz2eQvG5nmsEKNxvnBAyMWqONHK0b-MgnRs1MJWVOa-i7y-bd2bs_zDuwpo5GHdQe_U7jT5W0V_--RL9Rt-moFhFnUxW8vhdg-nGAXNTOZwMh6AjpkNXIhOj4JEUl2Zk0mHJGcA9TGFVL2WqratlqKVtRoWrZNfPq7-89JP60W4G3Z6AuGI4eUGVz6tV6BFOUTf4_-t8FGMA7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>815532975</pqid></control><display><type>article</type><title>Patterns of social-experience-related c- fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Hamilton, Derek A. ; Candelaria-Cook, Felicha T. ; Akers, Katherine G. ; Rice, James P. ; Maes, Levi I. ; Rosenberg, Martina ; Valenzuela, C. Fernando ; Savage, Daniel D.</creator><creatorcontrib>Hamilton, Derek A. ; Candelaria-Cook, Felicha T. ; Akers, Katherine G. ; Rice, James P. ; Maes, Levi I. ; Rosenberg, Martina ; Valenzuela, C. Fernando ; Savage, Daniel D.</creatorcontrib><description>Recent findings from our laboratory indicate that alterations in frontal cortex function, structural plasticity, and related social behaviors are persistent consequences of exposure to moderate levels of ethanol during prenatal brain development
[24]. Fetal-ethanol-related reductions in the expression of the immediate early genes (IEGs) c-
fos and
Arc and alterations in dendritic spine density in ventrolateral and medial aspects of frontal cortex suggest a dissociation reminiscent of that described by Kolb et al.
[38] in which these aspects of frontal cortex undergo reciprocal experience-dependent changes. In addition to providing a brief review of the available data on social behavior and frontal cortex function in fetal-ethanol-exposed rats, the present paper presents novel data on social-experience-related IEG expression in four regions of frontal cortex (Zilles LO, VLO, Fr1, Fr2) that are evaluated alongside our prior data from AID and Cg3. Social experience in normal rats was related to a distinct pattern of IEG expression in ventrolateral and medial aspects of frontal cortex, with generally greater expression observed in ventrolateral frontal cortex. In contrast, weaker expression was observed in all aspects of frontal cortex in ethanol-exposed rats, with the exception of an experience-related increase in the medial agranular cortex. Behaviors related to social investigation and wrestling/boxing were differentially correlated with patterns of activity-related IEG expression in the regions under investigation for saccharin- and ethanol-exposed rats. These observations suggest that recruitment and expression of IEGs in frontal cortex following social experience are potentially important for understanding the long-term consequences of moderate prenatal ethanol exposure on frontal cortex function, synaptic plasticity, and related behaviors.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2010.05.048</identifier><identifier>PMID: 20570698</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Cerebral Cortex - drug effects ; Cerebral Cortex - embryology ; Cerebral Cortex - metabolism ; Cytoskeletal Proteins - metabolism ; Ethanol - pharmacology ; Ethanol teratogenesis ; Female ; Gene Expression Regulation, Developmental - drug effects ; Genes, Immediate-Early - physiology ; Immediate early gene expression ; Male ; Nerve Tissue Proteins - metabolism ; Pregnancy ; Prenatal Exposure Delayed Effects - metabolism ; Prenatal Exposure Delayed Effects - physiopathology ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Saccharin - pharmacology ; Social Behavior</subject><ispartof>Behavioural brain research, 2010-12, Vol.214 (1), p.66-74</ispartof><rights>2010 Elsevier B.V.</rights><rights>Copyright 2010 Elsevier B.V. All rights reserved.</rights><rights>2010 Elsevier B.V. All rights reserved. 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-5f72354c76737742be728729bed5fbcff5e610dcac78df6282910cb0701faae43</citedby><cites>FETCH-LOGICAL-c548t-5f72354c76737742be728729bed5fbcff5e610dcac78df6282910cb0701faae43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432810004225$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20570698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hamilton, Derek A.</creatorcontrib><creatorcontrib>Candelaria-Cook, Felicha T.</creatorcontrib><creatorcontrib>Akers, Katherine G.</creatorcontrib><creatorcontrib>Rice, James P.</creatorcontrib><creatorcontrib>Maes, Levi I.</creatorcontrib><creatorcontrib>Rosenberg, Martina</creatorcontrib><creatorcontrib>Valenzuela, C. Fernando</creatorcontrib><creatorcontrib>Savage, Daniel D.</creatorcontrib><title>Patterns of social-experience-related c- fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>Recent findings from our laboratory indicate that alterations in frontal cortex function, structural plasticity, and related social behaviors are persistent consequences of exposure to moderate levels of ethanol during prenatal brain development
[24]. Fetal-ethanol-related reductions in the expression of the immediate early genes (IEGs) c-
fos and
Arc and alterations in dendritic spine density in ventrolateral and medial aspects of frontal cortex suggest a dissociation reminiscent of that described by Kolb et al.
[38] in which these aspects of frontal cortex undergo reciprocal experience-dependent changes. In addition to providing a brief review of the available data on social behavior and frontal cortex function in fetal-ethanol-exposed rats, the present paper presents novel data on social-experience-related IEG expression in four regions of frontal cortex (Zilles LO, VLO, Fr1, Fr2) that are evaluated alongside our prior data from AID and Cg3. Social experience in normal rats was related to a distinct pattern of IEG expression in ventrolateral and medial aspects of frontal cortex, with generally greater expression observed in ventrolateral frontal cortex. In contrast, weaker expression was observed in all aspects of frontal cortex in ethanol-exposed rats, with the exception of an experience-related increase in the medial agranular cortex. Behaviors related to social investigation and wrestling/boxing were differentially correlated with patterns of activity-related IEG expression in the regions under investigation for saccharin- and ethanol-exposed rats. These observations suggest that recruitment and expression of IEGs in frontal cortex following social experience are potentially important for understanding the long-term consequences of moderate prenatal ethanol exposure on frontal cortex function, synaptic plasticity, and related behaviors.</description><subject>Animals</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - embryology</subject><subject>Cerebral Cortex - metabolism</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Ethanol - pharmacology</subject><subject>Ethanol teratogenesis</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental - drug effects</subject><subject>Genes, Immediate-Early - physiology</subject><subject>Immediate early gene expression</subject><subject>Male</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - metabolism</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Saccharin - pharmacology</subject><subject>Social Behavior</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc2KFDEURgtRnHb0AdxIdq6qTVKVShWCMAz-wYAudB1Syc10mnTS3qSb8b18QFPd46AbVyHkfOeG-zXNS0bXjLLhzXY9z7jmtN6pWNN-fNSs2Ch5K0U_PW5WlRnavuPjRfMs5y2ltKeCPW0uOBWSDtO4an591aUAxkySIzkZr0MLd3tAD9FAixB0AUtMS1zKREdLrtCQSiDk7FMkPpKyAeIwxaIDMQmLN3DSoS55QVOuhpJI1sZsNNZEQrJLFioAJMARwomHstExBWIPlbkldUTUi3NGXTN24dJ-B7E8b544HTK8uD8vm-8f3n-7_tTefPn4-frqpjWiH0srnOSd6I0cZCdlz2eQvG5nmsEKNxvnBAyMWqONHK0b-MgnRs1MJWVOa-i7y-bd2bs_zDuwpo5GHdQe_U7jT5W0V_--RL9Rt-moFhFnUxW8vhdg-nGAXNTOZwMh6AjpkNXIhOj4JEUl2Zk0mHJGcA9TGFVL2WqratlqKVtRoWrZNfPq7-89JP60W4G3Z6AuGI4eUGVz6tV6BFOUTf4_-t8FGMA7</recordid><startdate>20101206</startdate><enddate>20101206</enddate><creator>Hamilton, Derek A.</creator><creator>Candelaria-Cook, Felicha T.</creator><creator>Akers, Katherine G.</creator><creator>Rice, James P.</creator><creator>Maes, Levi I.</creator><creator>Rosenberg, Martina</creator><creator>Valenzuela, C. Fernando</creator><creator>Savage, Daniel D.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20101206</creationdate><title>Patterns of social-experience-related c- fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development</title><author>Hamilton, Derek A. ; Candelaria-Cook, Felicha T. ; Akers, Katherine G. ; Rice, James P. ; Maes, Levi I. ; Rosenberg, Martina ; Valenzuela, C. Fernando ; Savage, Daniel D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-5f72354c76737742be728729bed5fbcff5e610dcac78df6282910cb0701faae43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - embryology</topic><topic>Cerebral Cortex - metabolism</topic><topic>Cytoskeletal Proteins - metabolism</topic><topic>Ethanol - pharmacology</topic><topic>Ethanol teratogenesis</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental - drug effects</topic><topic>Genes, Immediate-Early - physiology</topic><topic>Immediate early gene expression</topic><topic>Male</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - metabolism</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Rats</topic><topic>Saccharin - pharmacology</topic><topic>Social Behavior</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hamilton, Derek A.</creatorcontrib><creatorcontrib>Candelaria-Cook, Felicha T.</creatorcontrib><creatorcontrib>Akers, Katherine G.</creatorcontrib><creatorcontrib>Rice, James P.</creatorcontrib><creatorcontrib>Maes, Levi I.</creatorcontrib><creatorcontrib>Rosenberg, Martina</creatorcontrib><creatorcontrib>Valenzuela, C. Fernando</creatorcontrib><creatorcontrib>Savage, Daniel D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hamilton, Derek A.</au><au>Candelaria-Cook, Felicha T.</au><au>Akers, Katherine G.</au><au>Rice, James P.</au><au>Maes, Levi I.</au><au>Rosenberg, Martina</au><au>Valenzuela, C. Fernando</au><au>Savage, Daniel D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Patterns of social-experience-related c- fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2010-12-06</date><risdate>2010</risdate><volume>214</volume><issue>1</issue><spage>66</spage><epage>74</epage><pages>66-74</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><abstract>Recent findings from our laboratory indicate that alterations in frontal cortex function, structural plasticity, and related social behaviors are persistent consequences of exposure to moderate levels of ethanol during prenatal brain development
[24]. Fetal-ethanol-related reductions in the expression of the immediate early genes (IEGs) c-
fos and
Arc and alterations in dendritic spine density in ventrolateral and medial aspects of frontal cortex suggest a dissociation reminiscent of that described by Kolb et al.
[38] in which these aspects of frontal cortex undergo reciprocal experience-dependent changes. In addition to providing a brief review of the available data on social behavior and frontal cortex function in fetal-ethanol-exposed rats, the present paper presents novel data on social-experience-related IEG expression in four regions of frontal cortex (Zilles LO, VLO, Fr1, Fr2) that are evaluated alongside our prior data from AID and Cg3. Social experience in normal rats was related to a distinct pattern of IEG expression in ventrolateral and medial aspects of frontal cortex, with generally greater expression observed in ventrolateral frontal cortex. In contrast, weaker expression was observed in all aspects of frontal cortex in ethanol-exposed rats, with the exception of an experience-related increase in the medial agranular cortex. Behaviors related to social investigation and wrestling/boxing were differentially correlated with patterns of activity-related IEG expression in the regions under investigation for saccharin- and ethanol-exposed rats. These observations suggest that recruitment and expression of IEGs in frontal cortex following social experience are potentially important for understanding the long-term consequences of moderate prenatal ethanol exposure on frontal cortex function, synaptic plasticity, and related behaviors.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>20570698</pmid><doi>10.1016/j.bbr.2010.05.048</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0166-4328 |
| ispartof | Behavioural brain research, 2010-12, Vol.214 (1), p.66-74 |
| issn | 0166-4328 1872-7549 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_2910219 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Cerebral Cortex - drug effects Cerebral Cortex - embryology Cerebral Cortex - metabolism Cytoskeletal Proteins - metabolism Ethanol - pharmacology Ethanol teratogenesis Female Gene Expression Regulation, Developmental - drug effects Genes, Immediate-Early - physiology Immediate early gene expression Male Nerve Tissue Proteins - metabolism Pregnancy Prenatal Exposure Delayed Effects - metabolism Prenatal Exposure Delayed Effects - physiopathology Proto-Oncogene Proteins c-fos - metabolism Rats Saccharin - pharmacology Social Behavior |
| title | Patterns of social-experience-related c- fos and Arc expression in the frontal cortices of rats exposed to saccharin or moderate levels of ethanol during prenatal brain development |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T15%3A37%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Patterns%20of%20social-experience-related%20c-%20fos%20and%20Arc%20expression%20in%20the%20frontal%20cortices%20of%20rats%20exposed%20to%20saccharin%20or%20moderate%20levels%20of%20ethanol%20during%20prenatal%20brain%20development&rft.jtitle=Behavioural%20brain%20research&rft.au=Hamilton,%20Derek%20A.&rft.date=2010-12-06&rft.volume=214&rft.issue=1&rft.spage=66&rft.epage=74&rft.pages=66-74&rft.issn=0166-4328&rft.eissn=1872-7549&rft_id=info:doi/10.1016/j.bbr.2010.05.048&rft_dat=%3Cproquest_pubme%3E815532975%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=815532975&rft_id=info:pmid/20570698&rft_els_id=S0166432810004225&rfr_iscdi=true |