The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys
Abstract The surround suppression of the receptive field is important for basic visual information processing, such as orientation specificity. To date, the effects of aging on the strength of surround suppression are not clear. To address this issue, we carried out extracellular single-unit studies...
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| Veröffentlicht in: | Neuroscience 2010-08, Vol.169 (2), p.874-881 |
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| creator | Fu, Y Wang, X.S Wang, Y.C Zhang, J Liang, Z Zhou, Y.F Ma, Y.Y |
| description | Abstract The surround suppression of the receptive field is important for basic visual information processing, such as orientation specificity. To date, the effects of aging on the strength of surround suppression are not clear. To address this issue, we carried out extracellular single-unit studies of the receptive field properties of cells in the primary visual cortex (area V1) in young and old rhesus ( Macaca mulatta ) monkeys. When presented with the oriented central stimulus, we found that cells in old animals showed reduced orientation and direction selectivity compared with those in young animals. When presented with the oriented central stimulus together with the optimal surround stimulus, more selective cells {orientation bias (OB) ≥0.1; a bias of 0.1 is significant at the P |
| doi_str_mv | 10.1016/j.neuroscience.2010.05.015 |
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To date, the effects of aging on the strength of surround suppression are not clear. To address this issue, we carried out extracellular single-unit studies of the receptive field properties of cells in the primary visual cortex (area V1) in young and old rhesus ( Macaca mulatta ) monkeys. When presented with the oriented central stimulus, we found that cells in old animals showed reduced orientation and direction selectivity compared with those in young animals. When presented with the oriented central stimulus together with the optimal surround stimulus, more selective cells {orientation bias (OB) ≥0.1; a bias of 0.1 is significant at the P <0.005 level} in animals of both ages showed reduced orientation selectivity compared with the experiment that presented only the oriented central stimulus. When presented with the optimal central stimulus together with the oriented surround stimulus, cells in old animals showed reduced orientation and direction selectivity compared with young animals. Moreover, broadly tuned cells (OB<0.1) in old animals exhibited significantly reduced suppression indices that quantified the strength of the surround suppression of the receptive field, when compared with those in young animals. These results suggest that aging may seriously affect the surround suppression of the receptive field of V1 cells. Thus, the decreased strength of surround suppression of the receptive field may be one possible reason for the decreased stimulus selectivity of V1 cells previously found in the senescent brain. This work will contribute to an understanding of the physiological mechanisms mediating surround suppression of the receptive field.</description><identifier>ISSN: 0306-4522</identifier><identifier>EISSN: 1873-7544</identifier><identifier>DOI: 10.1016/j.neuroscience.2010.05.015</identifier><identifier>PMID: 20472034</identifier><identifier>CODEN: NRSCDN</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Aging ; Aging - physiology ; Animals ; Biological and medical sciences ; Eye and associated structures. Visual pathways and centers. Vision ; Fundamental and applied biological sciences. Psychology ; Macaca mulatta ; Male ; Neurology ; Neurons - physiology ; orientation selectivity ; Photic Stimulation ; primary visual cortex ; receptive field ; rhesus monkey ; surround inhibition ; Vertebrates: nervous system and sense organs ; Visual Cortex - cytology ; Visual Cortex - physiology ; Visual Perception - physiology</subject><ispartof>Neuroscience, 2010-08, Vol.169 (2), p.874-881</ispartof><rights>IBRO</rights><rights>2010 IBRO</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-1c932355100ee041c684a5ae6645f93a7c646984fb9d45687eadd418a458b3373</citedby><cites>FETCH-LOGICAL-c603t-1c932355100ee041c684a5ae6645f93a7c646984fb9d45687eadd418a458b3373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neuroscience.2010.05.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23087235$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20472034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fu, Y</creatorcontrib><creatorcontrib>Wang, X.S</creatorcontrib><creatorcontrib>Wang, Y.C</creatorcontrib><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Liang, Z</creatorcontrib><creatorcontrib>Zhou, Y.F</creatorcontrib><creatorcontrib>Ma, Y.Y</creatorcontrib><title>The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys</title><title>Neuroscience</title><addtitle>Neuroscience</addtitle><description>Abstract The surround suppression of the receptive field is important for basic visual information processing, such as orientation specificity. To date, the effects of aging on the strength of surround suppression are not clear. To address this issue, we carried out extracellular single-unit studies of the receptive field properties of cells in the primary visual cortex (area V1) in young and old rhesus ( Macaca mulatta ) monkeys. When presented with the oriented central stimulus, we found that cells in old animals showed reduced orientation and direction selectivity compared with those in young animals. When presented with the oriented central stimulus together with the optimal surround stimulus, more selective cells {orientation bias (OB) ≥0.1; a bias of 0.1 is significant at the P <0.005 level} in animals of both ages showed reduced orientation selectivity compared with the experiment that presented only the oriented central stimulus. When presented with the optimal central stimulus together with the oriented surround stimulus, cells in old animals showed reduced orientation and direction selectivity compared with young animals. Moreover, broadly tuned cells (OB<0.1) in old animals exhibited significantly reduced suppression indices that quantified the strength of the surround suppression of the receptive field, when compared with those in young animals. These results suggest that aging may seriously affect the surround suppression of the receptive field of V1 cells. Thus, the decreased strength of surround suppression of the receptive field may be one possible reason for the decreased stimulus selectivity of V1 cells previously found in the senescent brain. This work will contribute to an understanding of the physiological mechanisms mediating surround suppression of the receptive field.</description><subject>Aging</subject><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Neurology</subject><subject>Neurons - physiology</subject><subject>orientation selectivity</subject><subject>Photic Stimulation</subject><subject>primary visual cortex</subject><subject>receptive field</subject><subject>rhesus monkey</subject><subject>surround inhibition</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Visual Cortex - cytology</subject><subject>Visual Cortex - physiology</subject><subject>Visual Perception - physiology</subject><issn>0306-4522</issn><issn>1873-7544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuP0zAQgCMEYsvCX0AREuKUYsfPcFhptTyllTiwcLVcZ9y6pHaxk0r775moZVm4QC6OZj7P2PO5ql5QsqSEytfbZYQpp-ICRAfLlmCCiCWh4kG1oFqxRgnOH1YLwohsuGjbs-pJKVuCn-DscXXWEq5awvii8jcbqMF7cGOpk6_tOsR1nWI9YryMGeJ63MyJMuWcptjjz36foZSAEMYzONiP4QC1DzD0c-gbrR0MQ6lDrHcpfofb8rR65O1Q4NlpPa--vn93c_Wxuf784dPV5XXjJGFjQ13HWiYEJQSAcOqk5lZYkJIL3zGrnOSy09yvup4LqRXYvudUWy70ijHFzquLY939tNpB7yCO2Q5mn8PO5luTbDB_ZmLYmHU6mLbDnp3EAq9OBXL6MUEZzS6U-TY2QpqK0UoJTZgS_yQVY53umGBIvjmSDqWVDP7uPJSY2ajZmvtGzWzUEGHQKG5-fv9Gd1t_KUTg5QmwxdnBZxtdKL85RrTCmSL39sgBzv8QIJtTuz6gw9H0KfzfeS7-KuOGEAN2Rs9QtmnKEQ0bakpriPkyv8H5CeJ4CY5EsJ91_tt3</recordid><startdate>20100825</startdate><enddate>20100825</enddate><creator>Fu, Y</creator><creator>Wang, X.S</creator><creator>Wang, Y.C</creator><creator>Zhang, J</creator><creator>Liang, Z</creator><creator>Zhou, Y.F</creator><creator>Ma, Y.Y</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20100825</creationdate><title>The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys</title><author>Fu, Y ; Wang, X.S ; Wang, Y.C ; Zhang, J ; Liang, Z ; Zhou, Y.F ; Ma, Y.Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-1c932355100ee041c684a5ae6645f93a7c646984fb9d45687eadd418a458b3373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Aging</topic><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Neurology</topic><topic>Neurons - physiology</topic><topic>orientation selectivity</topic><topic>Photic Stimulation</topic><topic>primary visual cortex</topic><topic>receptive field</topic><topic>rhesus monkey</topic><topic>surround inhibition</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Visual Cortex - cytology</topic><topic>Visual Cortex - physiology</topic><topic>Visual Perception - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Y</creatorcontrib><creatorcontrib>Wang, X.S</creatorcontrib><creatorcontrib>Wang, Y.C</creatorcontrib><creatorcontrib>Zhang, J</creatorcontrib><creatorcontrib>Liang, Z</creatorcontrib><creatorcontrib>Zhou, Y.F</creatorcontrib><creatorcontrib>Ma, Y.Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Y</au><au>Wang, X.S</au><au>Wang, Y.C</au><au>Zhang, J</au><au>Liang, Z</au><au>Zhou, Y.F</au><au>Ma, Y.Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2010-08-25</date><risdate>2010</risdate><volume>169</volume><issue>2</issue><spage>874</spage><epage>881</epage><pages>874-881</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><coden>NRSCDN</coden><abstract>Abstract The surround suppression of the receptive field is important for basic visual information processing, such as orientation specificity. To date, the effects of aging on the strength of surround suppression are not clear. To address this issue, we carried out extracellular single-unit studies of the receptive field properties of cells in the primary visual cortex (area V1) in young and old rhesus ( Macaca mulatta ) monkeys. When presented with the oriented central stimulus, we found that cells in old animals showed reduced orientation and direction selectivity compared with those in young animals. When presented with the oriented central stimulus together with the optimal surround stimulus, more selective cells {orientation bias (OB) ≥0.1; a bias of 0.1 is significant at the P <0.005 level} in animals of both ages showed reduced orientation selectivity compared with the experiment that presented only the oriented central stimulus. When presented with the optimal central stimulus together with the oriented surround stimulus, cells in old animals showed reduced orientation and direction selectivity compared with young animals. Moreover, broadly tuned cells (OB<0.1) in old animals exhibited significantly reduced suppression indices that quantified the strength of the surround suppression of the receptive field, when compared with those in young animals. These results suggest that aging may seriously affect the surround suppression of the receptive field of V1 cells. Thus, the decreased strength of surround suppression of the receptive field may be one possible reason for the decreased stimulus selectivity of V1 cells previously found in the senescent brain. This work will contribute to an understanding of the physiological mechanisms mediating surround suppression of the receptive field.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>20472034</pmid><doi>10.1016/j.neuroscience.2010.05.015</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging Aging - physiology Animals Biological and medical sciences Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Macaca mulatta Male Neurology Neurons - physiology orientation selectivity Photic Stimulation primary visual cortex receptive field rhesus monkey surround inhibition Vertebrates: nervous system and sense organs Visual Cortex - cytology Visual Cortex - physiology Visual Perception - physiology |
| title | The effects of aging on the strength of surround suppression of receptive field of V1 cells in monkeys |
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