A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes
Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. Gene interaction networks constructed from six independent data sets overlapped stro...
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| Veröffentlicht in: | Genome research 2010-08, Vol.20 (8), p.1122-1132 |
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| creator | Lin, Andy Wang, Richard T Ahn, Sangtae Park, Christopher C Smith, Desmond J |
| description | Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. Gene interaction networks constructed from six independent data sets overlapped strongly. Combining the data sets resulted in a network of more than seven million interactions, almost all attractive. This network overlapped with protein-protein interaction networks on multiple measures and also confirmed the relationship between essentiality and centrality. In contrast to other biological networks, the radiation hybrid network did not show a scale-free distribution of connectivity but was Gaussian-like, suggesting a closer approach to saturation. The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell. |
| doi_str_mv | 10.1101/gr.104216.109 |
| format | Article |
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Gene interaction networks constructed from six independent data sets overlapped strongly. Combining the data sets resulted in a network of more than seven million interactions, almost all attractive. This network overlapped with protein-protein interaction networks on multiple measures and also confirmed the relationship between essentiality and centrality. In contrast to other biological networks, the radiation hybrid network did not show a scale-free distribution of connectivity but was Gaussian-like, suggesting a closer approach to saturation. The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell.</description><identifier>ISSN: 1088-9051</identifier><identifier>EISSN: 1549-5469</identifier><identifier>DOI: 10.1101/gr.104216.109</identifier><identifier>PMID: 20508145</identifier><language>eng</language><publisher>United States: Cold Spring Harbor Laboratory Press</publisher><subject>Female ; Gene Regulatory Networks ; Genome, Human - genetics ; Genome-Wide Association Study ; Genotype ; Humans ; Male ; Method ; Protein Interaction Mapping ; Radiation Hybrid Mapping</subject><ispartof>Genome research, 2010-08, Vol.20 (8), p.1122-1132</ispartof><rights>Copyright © 2010 by Cold Spring Harbor Laboratory Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-ded474bac2d215dcda7438b59f6a9f032215539e03903f0dc01a6bd58a23acca3</citedby><cites>FETCH-LOGICAL-c386t-ded474bac2d215dcda7438b59f6a9f032215539e03903f0dc01a6bd58a23acca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909575/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909575/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20508145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Andy</creatorcontrib><creatorcontrib>Wang, Richard T</creatorcontrib><creatorcontrib>Ahn, Sangtae</creatorcontrib><creatorcontrib>Park, Christopher C</creatorcontrib><creatorcontrib>Smith, Desmond J</creatorcontrib><title>A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes</title><title>Genome research</title><addtitle>Genome Res</addtitle><description>Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. Gene interaction networks constructed from six independent data sets overlapped strongly. Combining the data sets resulted in a network of more than seven million interactions, almost all attractive. This network overlapped with protein-protein interaction networks on multiple measures and also confirmed the relationship between essentiality and centrality. In contrast to other biological networks, the radiation hybrid network did not show a scale-free distribution of connectivity but was Gaussian-like, suggesting a closer approach to saturation. The radiation hybrid (RH) network constitutes a platform for understanding the systems biology of the mammalian cell.</description><subject>Female</subject><subject>Gene Regulatory Networks</subject><subject>Genome, Human - genetics</subject><subject>Genome-Wide Association Study</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Method</subject><subject>Protein Interaction Mapping</subject><subject>Radiation Hybrid Mapping</subject><issn>1088-9051</issn><issn>1549-5469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1P4zAQtdAiCoUjV5TbngLj2E7tCxJCy4eExAUkbtbEnrRGTVzsdFH__aYU0HJ6M_Oe3ozmMXbK4Zxz4BfzdM5BVrweweyxQ66kKZWsza-xBq1LA4pP2FHOrwAgpNYHbFKBAs2lOmQvV8Wc-thR-R48FR2uitgWi3WH_ZagIbgi9AMldEOIfR6bllIiX7QpdkVCH3BLFItNk4L_MBs2K8rHbL_FZaaTT5yy55s_T9d35cPj7f311UPphK6H0pOXM9mgq3zFlXceZ1LoRpm2RtOCqMapEoZAGBAteAcc68YrjZVA51BM2eXOd7VuOvKO-iHh0q5S6DBtbMRgfzJ9WNh5_GsrA0bN1Gjw-9Mgxbc15cF2ITtaLrGnuM52JrWRIBUfleVO6VLMOVH7vYWD3YZh58nuwhjBjPqz_0_7Vn99X_wD0GWHjw</recordid><startdate>201008</startdate><enddate>201008</enddate><creator>Lin, Andy</creator><creator>Wang, Richard T</creator><creator>Ahn, Sangtae</creator><creator>Park, Christopher C</creator><creator>Smith, Desmond J</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201008</creationdate><title>A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes</title><author>Lin, Andy ; Wang, Richard T ; Ahn, Sangtae ; Park, Christopher C ; Smith, Desmond J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-ded474bac2d215dcda7438b59f6a9f032215539e03903f0dc01a6bd58a23acca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Female</topic><topic>Gene Regulatory Networks</topic><topic>Genome, Human - genetics</topic><topic>Genome-Wide Association Study</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Method</topic><topic>Protein Interaction Mapping</topic><topic>Radiation Hybrid Mapping</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Andy</creatorcontrib><creatorcontrib>Wang, Richard T</creatorcontrib><creatorcontrib>Ahn, Sangtae</creatorcontrib><creatorcontrib>Park, Christopher C</creatorcontrib><creatorcontrib>Smith, Desmond J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Genome research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Andy</au><au>Wang, Richard T</au><au>Ahn, Sangtae</au><au>Park, Christopher C</au><au>Smith, Desmond J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes</atitle><jtitle>Genome research</jtitle><addtitle>Genome Res</addtitle><date>2010-08</date><risdate>2010</risdate><volume>20</volume><issue>8</issue><spage>1122</spage><epage>1132</epage><pages>1122-1132</pages><issn>1088-9051</issn><eissn>1549-5469</eissn><abstract>Using radiation hybrid genotyping data, 99% of all possible gene pairs across the mammalian genome were tested for interactions based on co-retention frequencies higher (attraction) or lower (repulsion) than chance. 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| ispartof | Genome research, 2010-08, Vol.20 (8), p.1122-1132 |
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| source | MEDLINE; PubMed Central; Alma/SFX Local Collection |
| subjects | Female Gene Regulatory Networks Genome, Human - genetics Genome-Wide Association Study Genotype Humans Male Method Protein Interaction Mapping Radiation Hybrid Mapping |
| title | A genome-wide map of human genetic interactions inferred from radiation hybrid genotypes |
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