Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline

Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction. Common genetic variations alter the risk of developing organ dysfunction when choline deficient, probably by causing metabolic inefficiencies that should be detectable even while ingesting a normal choline-adequate...

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Veröffentlicht in:	The FASEB journal 2010-08, Vol.24 (8), p.2962-2975
Hauptverfasser:	Sha, Wei, da Costa, Kerry-Ann, Fischer, Leslie M, Milburn, Michael V, Lawton, Kay A, Berger, Alvin, Jia, Wei, Zeisel, Steven H
Format:	Artikel
Sprache:	eng
Schlagworte:	Choline - administration & dosage Choline Deficiency - complications Diet Fats - analysis fatty liver Humans Liver - chemistry Liver Diseases - etiology metabolomics Metabolomics - methods PEMT plasma Predictive Value of Tests Research Communications
Online-Zugang:	Volltext
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