Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex

Proteins of the death domain (DD) superfamily mediate assembly of oligomeric signaling complexes for the activation of caspases and kinases via unknown mechanisms. Here we report the crystal structure of the PIDD DD and RAIDD DD complex, which forms the core of the caspase-2-activating complex PIDDo...

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Veröffentlicht in:	Cell 2007-02, Vol.128 (3), p.533-546
Hauptverfasser:	Park, Hyun Ho, Logette, Emmanuelle, Raunser, Stefan, Cuenin, Solange, Walz, Thomas, Tschopp, Jurg, Wu, Hao
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Caspase 2 - metabolism CELLBIO CELLIMMUNO CRADD Signaling Adaptor Protein - chemistry CRADD Signaling Adaptor Protein - genetics CRADD Signaling Adaptor Protein - metabolism Crystallography, X-Ray Death Domain Receptor Signaling Adaptor Proteins - chemistry Death Domain Receptor Signaling Adaptor Proteins - genetics Death Domain Receptor Signaling Adaptor Proteins - metabolism Models, Molecular Molecular Sequence Data Multiprotein Complexes - metabolism Mutagenesis, Site-Directed Protein Conformation Protein Structure, Tertiary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism
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