Dynamics of accommodative fatigue in rhesus monkeys and humans
Changes in accommodative dynamics with repeated accommodation were studied in three anesthetized rhesus monkeys and two conscious humans. Maximum accommodation was centrally stimulated via the Edinger–Westphal nucleus in monkeys with a 4 s on, 4 s off paradigm (4 × 4) for 17 min, 4 × 1.5 for 27 min...
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| Veröffentlicht in: | Vision research (Oxford) 2005, Vol.45 (2), p.181-191 |
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| creator | Vilupuru, Abhiram S. Kasthurirangan, Sanjeev Glasser, Adrian |
| description | Changes in accommodative dynamics with repeated accommodation were studied in three anesthetized rhesus monkeys and two conscious humans. Maximum accommodation was centrally stimulated via the Edinger–Westphal nucleus in monkeys with a 4 s on, 4 s off paradigm (4
×
4) for 17 min, 4
×
1.5 for 27 min and 2
×
1 for 16 min. Humans accommodated repeatedly to visual targets (5
×
5; 5D and 2
×
2; 6D) for 30 min. In all cases, accommodation was sustained throughout. The anesthetized monkeys showed inter-individual variability in the extent of changes in accommodative dynamics over time while no systematic changes were detected in the human accommodative responses. Little accommodative fatigue was found compared to previous studies which have reported a complete loss of accommodation after 5 min of repeated stimulation in monkeys. |
| doi_str_mv | 10.1016/j.visres.2004.07.036 |
| format | Article |
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×
4) for 17 min, 4
×
1.5 for 27 min and 2
×
1 for 16 min. Humans accommodated repeatedly to visual targets (5
×
5; 5D and 2
×
2; 6D) for 30 min. In all cases, accommodation was sustained throughout. The anesthetized monkeys showed inter-individual variability in the extent of changes in accommodative dynamics over time while no systematic changes were detected in the human accommodative responses. Little accommodative fatigue was found compared to previous studies which have reported a complete loss of accommodation after 5 min of repeated stimulation in monkeys.</description><identifier>ISSN: 0042-6989</identifier><identifier>EISSN: 1878-5646</identifier><identifier>DOI: 10.1016/j.visres.2004.07.036</identifier><identifier>PMID: 15581919</identifier><identifier>CODEN: VISRAM</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Accommodation ; Accommodation, Ocular - physiology ; Accommodative dynamics ; Adult ; Amplitude of accommodation ; Animals ; Biological and medical sciences ; Ciliary Body - physiology ; Electric Stimulation - methods ; Eye and associated structures. Visual pathways and centers. Vision ; Fatigue ; Fundamental and applied biological sciences. Psychology ; Humans ; Lens, Crystalline - physiology ; Macaca mulatta ; Main sequence ratio ; Muscle Fatigue - physiology ; Species Specificity ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Vision research (Oxford), 2005, Vol.45 (2), p.181-191</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><rights>2004 Elsevier Ltd. All rights reserved 2004</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-82a434023ad48ee6c12fe1c86578c9f50493ed24e44199a861ac8cb4e352324e3</citedby><cites>FETCH-LOGICAL-c489t-82a434023ad48ee6c12fe1c86578c9f50493ed24e44199a861ac8cb4e352324e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.visres.2004.07.036$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,777,781,882,3537,4010,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16372834$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15581919$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vilupuru, Abhiram S.</creatorcontrib><creatorcontrib>Kasthurirangan, Sanjeev</creatorcontrib><creatorcontrib>Glasser, Adrian</creatorcontrib><title>Dynamics of accommodative fatigue in rhesus monkeys and humans</title><title>Vision research (Oxford)</title><addtitle>Vision Res</addtitle><description>Changes in accommodative dynamics with repeated accommodation were studied in three anesthetized rhesus monkeys and two conscious humans. Maximum accommodation was centrally stimulated via the Edinger–Westphal nucleus in monkeys with a 4 s on, 4 s off paradigm (4
×
4) for 17 min, 4
×
1.5 for 27 min and 2
×
1 for 16 min. Humans accommodated repeatedly to visual targets (5
×
5; 5D and 2
×
2; 6D) for 30 min. In all cases, accommodation was sustained throughout. The anesthetized monkeys showed inter-individual variability in the extent of changes in accommodative dynamics over time while no systematic changes were detected in the human accommodative responses. Little accommodative fatigue was found compared to previous studies which have reported a complete loss of accommodation after 5 min of repeated stimulation in monkeys.</description><subject>Accommodation</subject><subject>Accommodation, Ocular - physiology</subject><subject>Accommodative dynamics</subject><subject>Adult</subject><subject>Amplitude of accommodation</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Ciliary Body - physiology</subject><subject>Electric Stimulation - methods</subject><subject>Eye and associated structures. Visual pathways and centers. Vision</subject><subject>Fatigue</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lens, Crystalline - physiology</subject><subject>Macaca mulatta</subject><subject>Main sequence ratio</subject><subject>Muscle Fatigue - physiology</subject><subject>Species Specificity</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0042-6989</issn><issn>1878-5646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi1ERZfCP0AoF3pL6q849qVS1RaKVIkLnC3XmXS9JHbrSVbaf4-rXbFw6WkkzzOvZx5CPjHaMMrUxabZBsyADadUNrRrqFBvyIrpTtetkuotWZUGr5XR5pS8R9xQSruWm3fklLWtZoaZFbm82UU3BY9VGirnfZqm1Ls5bKEaSnlcoAqxymvABaspxd-ww8rFvlovk4v4gZwMbkT4eKhn5NfX25_Xd_X9j2_fr6_uay-1mWvNnRSScuF6qQGUZ3wA5rVqO-3N0FJpBPRcgpTMGKcVc177Bwmi5aI8izNyuc99Wh4m6D3EObvRPuUwubyzyQX7fyeGtX1MW8sN1YLTEnB-CMjpeQGc7RTQwzi6CGlBqzohpDJdAeUe9Dlh8Tv8_YRR-yLebuxevH0Rb2lni_gy9vnfBY9DB9MF-HIAHHo3DtlFH_DIKdFxLeTxUig6twGyRR8geuhDBj_bPoXXN_kD2WOkTA</recordid><startdate>2005</startdate><enddate>2005</enddate><creator>Vilupuru, Abhiram S.</creator><creator>Kasthurirangan, Sanjeev</creator><creator>Glasser, Adrian</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2005</creationdate><title>Dynamics of accommodative fatigue in rhesus monkeys and humans</title><author>Vilupuru, Abhiram S. ; Kasthurirangan, Sanjeev ; Glasser, Adrian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-82a434023ad48ee6c12fe1c86578c9f50493ed24e44199a861ac8cb4e352324e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Accommodation</topic><topic>Accommodation, Ocular - physiology</topic><topic>Accommodative dynamics</topic><topic>Adult</topic><topic>Amplitude of accommodation</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Ciliary Body - physiology</topic><topic>Electric Stimulation - methods</topic><topic>Eye and associated structures. Visual pathways and centers. Vision</topic><topic>Fatigue</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lens, Crystalline - physiology</topic><topic>Macaca mulatta</topic><topic>Main sequence ratio</topic><topic>Muscle Fatigue - physiology</topic><topic>Species Specificity</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vilupuru, Abhiram S.</creatorcontrib><creatorcontrib>Kasthurirangan, Sanjeev</creatorcontrib><creatorcontrib>Glasser, Adrian</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vision research (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vilupuru, Abhiram S.</au><au>Kasthurirangan, Sanjeev</au><au>Glasser, Adrian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dynamics of accommodative fatigue in rhesus monkeys and humans</atitle><jtitle>Vision research (Oxford)</jtitle><addtitle>Vision Res</addtitle><date>2005</date><risdate>2005</risdate><volume>45</volume><issue>2</issue><spage>181</spage><epage>191</epage><pages>181-191</pages><issn>0042-6989</issn><eissn>1878-5646</eissn><coden>VISRAM</coden><abstract>Changes in accommodative dynamics with repeated accommodation were studied in three anesthetized rhesus monkeys and two conscious humans. 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×
4) for 17 min, 4
×
1.5 for 27 min and 2
×
1 for 16 min. Humans accommodated repeatedly to visual targets (5
×
5; 5D and 2
×
2; 6D) for 30 min. In all cases, accommodation was sustained throughout. The anesthetized monkeys showed inter-individual variability in the extent of changes in accommodative dynamics over time while no systematic changes were detected in the human accommodative responses. Little accommodative fatigue was found compared to previous studies which have reported a complete loss of accommodation after 5 min of repeated stimulation in monkeys.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15581919</pmid><doi>10.1016/j.visres.2004.07.036</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Vision research (Oxford), 2005, Vol.45 (2), p.181-191 |
| issn | 0042-6989 1878-5646 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | Accommodation Accommodation, Ocular - physiology Accommodative dynamics Adult Amplitude of accommodation Animals Biological and medical sciences Ciliary Body - physiology Electric Stimulation - methods Eye and associated structures. Visual pathways and centers. Vision Fatigue Fundamental and applied biological sciences. Psychology Humans Lens, Crystalline - physiology Macaca mulatta Main sequence ratio Muscle Fatigue - physiology Species Specificity Time Factors Vertebrates: nervous system and sense organs |
| title | Dynamics of accommodative fatigue in rhesus monkeys and humans |
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