Structural Energetics of the Adenine Tract from an Intrinsic Transcription Terminator

Intrinsic transcription termination sites generally contain a tract of adenines in the DNA template that yields a tract of uracils at the 3′ end of the nascent RNA. To understand how this base sequence contributes to termination of transcription, we have investigated two nucleic acid structures. The...

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Veröffentlicht in:	Journal of molecular biology 2010-04, Vol.397 (3), p.677-688
Hauptverfasser:	Huang, Yuegao, Weng, Xiaoli, Russu, Irina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine Adenine - chemistry adenine tracts base-pair opening DNA - chemistry DNA-Directed RNA Polymerases - metabolism intrinsic transcription termination Nuclear Magnetic Resonance, Biomolecular proton exchange RNA - chemistry RNA–DNA hybrids Terminator Regions, Genetic - genetics Thermodynamics Transcription, Genetic - genetics Uracil - chemistry
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