All trans retinoic acid nanodisks enhance retinoic acid receptor mediated apoptosis and cell cycle arrest in mantle cell lymphoma

Summary Mantle cell lymphoma (MCL) is characterized by translocation t(11;14)(q13;q32), aggressive clinical behaviour, and poor patient outcomes following conventional chemotherapy. New treatment approaches are needed that target novel biological pathways. All trans retinoic acid (ATRA) is a key ret...

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Veröffentlicht in:	British journal of haematology 2010-07, Vol.150 (2), p.158-169
Hauptverfasser:	Singh, Amareshwar T.K., Evens, Andrew M., Anderson, Reilly J., Beckstead, Jennifer A., Sankar, Natesan, Sassano, Antonella, Bhalla, Savita, Yang, Shuo, Platanias, Leonidas C., Forte, Trudy M., Ryan, Robert O., Gordon, Leo I.
Format:	Artikel
Sprache:	eng
Schlagworte:	all trans retinoic acid (ATRA) Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology apoptosis Apoptosis - drug effects Benzoates - pharmacology Biological and medical sciences Cell Cycle - drug effects Cell Cycle Proteins - biosynthesis Cell Cycle Proteins - drug effects Chromans - pharmacology Drug Delivery Systems Drug Evaluation, Preclinical Guanine Nucleotide Exchange Factors - biosynthesis Guanine Nucleotide Exchange Factors - drug effects Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Mantle-Cell - metabolism Lymphoma, Mantle-Cell - pathology mantle cell lymphoma Medical sciences nanodisks Nanoparticles Neoplasm Proteins - biosynthesis Neoplasm Proteins - drug effects Nuclear Proteins - biosynthesis Nuclear Proteins - drug effects reactive oxygen species Reactive Oxygen Species - metabolism Receptors, Retinoic Acid - antagonists & inhibitors Receptors, Retinoic Acid - drug effects Receptors, Retinoic Acid - metabolism Retinoid X Receptors - drug effects Retinoid X Receptors - metabolism Transcription, Genetic - drug effects Tretinoin - administration & dosage Tretinoin - pharmacology Tumor Cells, Cultured
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