Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial
Background: To evaluate whether a fermented dairy drink containing the probiotic strain Lactobacillus casei DN-114 001 could reduce the incidence of common infectious diseases (CIDs) and the change of behavior because of illness in children. Subjects/Methods: We conducted a double-blinded, randomize...
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| Veröffentlicht in: | European journal of clinical nutrition 2010-07, Vol.64 (7), p.669-677 |
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| creator | Merenstein, D Murphy, M Fokar, A Hernandez, R.K Park, H Nsouli, H Sanders, M.E Davis, B.A Niborski, V Tondu, F Shara, N.M |
| description | Background: To evaluate whether a fermented dairy drink containing the probiotic strain Lactobacillus casei DN-114 001 could reduce the incidence of common infectious diseases (CIDs) and the change of behavior because of illness in children. Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled allocation concealment clinical trial in the Washington, DC metropolitan area. Participants were 638 children 3–6 years old in daycare/schools. The intervention was a fermented dairy drink containing a specific probiotic strain or matching placebo with no live cultures for 90 consecutive days. Two primary outcomes were assessed: incidence of CIDs and change of behavior because of illness (both assessed by parental report). Results: The rate of change of behavior because of illness was similar among active and control groups. However, the incidence rate for CIDs in the active group (0.0782) is 19% lower than that of the control group (0.0986) (incidence rate ratio=0.81, 95% CI: 0.65, 099) P=0.046. Conclusions: Daily intake of a fermented dairy drink containing the probiotic strain L. casei DN-114 001 showed some promise in reducing overall incidence of illness, but was primarily driven by gastrointestinal infections and there were no differences in change of behavior. |
| doi_str_mv | 10.1038/ejcn.2010.65 |
| format | Article |
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Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled allocation concealment clinical trial in the Washington, DC metropolitan area. Participants were 638 children 3–6 years old in daycare/schools. The intervention was a fermented dairy drink containing a specific probiotic strain or matching placebo with no live cultures for 90 consecutive days. Two primary outcomes were assessed: incidence of CIDs and change of behavior because of illness (both assessed by parental report). Results: The rate of change of behavior because of illness was similar among active and control groups. However, the incidence rate for CIDs in the active group (0.0782) is 19% lower than that of the control group (0.0986) (incidence rate ratio=0.81, 95% CI: 0.65, 099) P=0.046. Conclusions: Daily intake of a fermented dairy drink containing the probiotic strain L. casei DN-114 001 showed some promise in reducing overall incidence of illness, but was primarily driven by gastrointestinal infections and there were no differences in change of behavior.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/ejcn.2010.65</identifier><identifier>PMID: 20485304</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/2779/109 ; 692/699/255 ; 692/700/565/2072 ; antimicrobial properties ; attitudes and opinions ; beverages ; Child ; child nutrition ; Child, Preschool ; Children & youth ; Clinical Nutrition ; Clinical trials ; Communicable Disease Control ; Communicable Diseases - epidemiology ; Communicable diseases in children ; Dairy Products ; daycare absences ; diet ; dietary supplements ; disease incidence ; disease prevention ; District of Columbia - epidemiology ; Double-Blind Method ; DRINK study ; Enriched foods ; Epidemiology ; experimental diets ; Female ; Fermentation ; Fermented milk ; Gastrointestinal diseases ; Gastrointestinal Diseases - epidemiology ; Gastrointestinal Diseases - prevention & control ; Health aspects ; health status ; human behavior ; human health ; Humans ; Illnesses ; Incidence ; infection ; Infectious diseases ; Internal Medicine ; Lactobacillus ; Lactobacillus casei ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metropolitan areas ; Nutrition research ; Original ; original-article ; parents ; preschool children ; Prevention ; Probiotics ; Probiotics - therapeutic use ; Public Health ; randomized clinical trials ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - prevention & control ; school absences ; Schools</subject><ispartof>European journal of clinical nutrition, 2010-07, Vol.64 (7), p.669-677</ispartof><rights>The Author(s) 2010</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2010</rights><rights>Copyright © 2010 Macmillan Publishers Limited 2010 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c640t-dd97e8b37df2c4cfaa7a98f34747865bf899103987f7694e3524092c76d592233</citedby><cites>FETCH-LOGICAL-c640t-dd97e8b37df2c4cfaa7a98f34747865bf899103987f7694e3524092c76d592233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,781,785,886,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20485304$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Merenstein, D</creatorcontrib><creatorcontrib>Murphy, M</creatorcontrib><creatorcontrib>Fokar, A</creatorcontrib><creatorcontrib>Hernandez, R.K</creatorcontrib><creatorcontrib>Park, H</creatorcontrib><creatorcontrib>Nsouli, H</creatorcontrib><creatorcontrib>Sanders, M.E</creatorcontrib><creatorcontrib>Davis, B.A</creatorcontrib><creatorcontrib>Niborski, V</creatorcontrib><creatorcontrib>Tondu, F</creatorcontrib><creatorcontrib>Shara, N.M</creatorcontrib><title>Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background: To evaluate whether a fermented dairy drink containing the probiotic strain Lactobacillus casei DN-114 001 could reduce the incidence of common infectious diseases (CIDs) and the change of behavior because of illness in children. Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled allocation concealment clinical trial in the Washington, DC metropolitan area. Participants were 638 children 3–6 years old in daycare/schools. The intervention was a fermented dairy drink containing a specific probiotic strain or matching placebo with no live cultures for 90 consecutive days. Two primary outcomes were assessed: incidence of CIDs and change of behavior because of illness (both assessed by parental report). Results: The rate of change of behavior because of illness was similar among active and control groups. However, the incidence rate for CIDs in the active group (0.0782) is 19% lower than that of the control group (0.0986) (incidence rate ratio=0.81, 95% CI: 0.65, 099) P=0.046. Conclusions: Daily intake of a fermented dairy drink containing the probiotic strain L. casei DN-114 001 showed some promise in reducing overall incidence of illness, but was primarily driven by gastrointestinal infections and there were no differences in change of behavior.</description><subject>692/308/2779/109</subject><subject>692/699/255</subject><subject>692/700/565/2072</subject><subject>antimicrobial properties</subject><subject>attitudes and opinions</subject><subject>beverages</subject><subject>Child</subject><subject>child nutrition</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Clinical Nutrition</subject><subject>Clinical trials</subject><subject>Communicable Disease Control</subject><subject>Communicable Diseases - epidemiology</subject><subject>Communicable diseases in children</subject><subject>Dairy Products</subject><subject>daycare absences</subject><subject>diet</subject><subject>dietary supplements</subject><subject>disease incidence</subject><subject>disease prevention</subject><subject>District of Columbia - epidemiology</subject><subject>Double-Blind Method</subject><subject>DRINK study</subject><subject>Enriched foods</subject><subject>Epidemiology</subject><subject>experimental diets</subject><subject>Female</subject><subject>Fermentation</subject><subject>Fermented milk</subject><subject>Gastrointestinal diseases</subject><subject>Gastrointestinal Diseases - epidemiology</subject><subject>Gastrointestinal Diseases - prevention & control</subject><subject>Health aspects</subject><subject>health status</subject><subject>human behavior</subject><subject>human health</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Incidence</subject><subject>infection</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Lactobacillus</subject><subject>Lactobacillus casei</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metropolitan areas</subject><subject>Nutrition research</subject><subject>Original</subject><subject>original-article</subject><subject>parents</subject><subject>preschool children</subject><subject>Prevention</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Public Health</subject><subject>randomized clinical trials</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - prevention & control</subject><subject>school absences</subject><subject>Schools</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFk8tu1DAUhiMEoqWwYw1WkbhITXFiJ3ZYIFUtl4qqSEDXlmOfzLj12IPtIJUH5jlwZkovqAhlEdn_d_5zSU5RPK7wboUJfw2nyu3WOB_b5k6xWVHWlk1L8d1iE3cNLQnGbKN4EOMpxllk9f1io8aUNwTTzeLXSQTkByTRAGEBLoFGWppwjpbB98Yno5AOxp0h5V2Sxhk3Q0dSJd9LZawdI1IygkEvD47LqqIoJ3mFkkcaVICsoDQHFGRaZckBDmJExqEzo-OblXjw5fD4E4pp1OdoDy1lMrmM0gezqmYHaT_2FsreGpdPKqdMEMognfYL83MillYq6H05lRi8tbDicq1KWpSCkfZhcW-QNsKji_dWcfL-3bf9j-XR5w-H-3tHpcoTS6XWHQPeE6aHWlE1SMlkxwdCGWW8bfqBd10eesfZwNqOAmlqirtasVY3XV0TslW8Xfsux34BWuUWgrRiGcxChnPhpRE3FWfmYuZ_iLrDLWtwNnhxYRD89xFiEgsTFVgrHfgxCtbQhlSsbv5PEtLSmlaT5_Zf5Kkfg8tzEA3PP07DOc3QszU0kxaEcYPP9anJUuzVpMIdbSqeqfIWagYOcjPewWDy9Q1-9xY-PxoWRt0a8PxawBykTfPo7ZiMd_EmuLMGVfAxBhguh1xhMS2GmBZDTIsh2mlaT65_mEv4zyZcdRaz5GYQrob0D8Ona36QXshZMFGcfM0iwRVvOe8w-Q3iOiCx</recordid><startdate>20100701</startdate><enddate>20100701</enddate><creator>Merenstein, D</creator><creator>Murphy, M</creator><creator>Fokar, A</creator><creator>Hernandez, R.K</creator><creator>Park, H</creator><creator>Nsouli, H</creator><creator>Sanders, M.E</creator><creator>Davis, B.A</creator><creator>Niborski, V</creator><creator>Tondu, F</creator><creator>Shara, N.M</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>5PM</scope></search><sort><creationdate>20100701</creationdate><title>Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial</title><author>Merenstein, D ; Murphy, M ; Fokar, A ; Hernandez, R.K ; Park, H ; Nsouli, H ; Sanders, M.E ; Davis, B.A ; Niborski, V ; Tondu, F ; Shara, N.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c640t-dd97e8b37df2c4cfaa7a98f34747865bf899103987f7694e3524092c76d592233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>692/308/2779/109</topic><topic>692/699/255</topic><topic>692/700/565/2072</topic><topic>antimicrobial properties</topic><topic>attitudes and opinions</topic><topic>beverages</topic><topic>Child</topic><topic>child nutrition</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Clinical Nutrition</topic><topic>Clinical trials</topic><topic>Communicable Disease Control</topic><topic>Communicable Diseases - 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Subjects/Methods: We conducted a double-blinded, randomized, placebo-controlled allocation concealment clinical trial in the Washington, DC metropolitan area. Participants were 638 children 3–6 years old in daycare/schools. The intervention was a fermented dairy drink containing a specific probiotic strain or matching placebo with no live cultures for 90 consecutive days. Two primary outcomes were assessed: incidence of CIDs and change of behavior because of illness (both assessed by parental report). Results: The rate of change of behavior because of illness was similar among active and control groups. However, the incidence rate for CIDs in the active group (0.0782) is 19% lower than that of the control group (0.0986) (incidence rate ratio=0.81, 95% CI: 0.65, 099) P=0.046. 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| ispartof | European journal of clinical nutrition, 2010-07, Vol.64 (7), p.669-677 |
| issn | 0954-3007 1476-5640 |
| language | eng |
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| subjects | 692/308/2779/109 692/699/255 692/700/565/2072 antimicrobial properties attitudes and opinions beverages Child child nutrition Child, Preschool Children & youth Clinical Nutrition Clinical trials Communicable Disease Control Communicable Diseases - epidemiology Communicable diseases in children Dairy Products daycare absences diet dietary supplements disease incidence disease prevention District of Columbia - epidemiology Double-Blind Method DRINK study Enriched foods Epidemiology experimental diets Female Fermentation Fermented milk Gastrointestinal diseases Gastrointestinal Diseases - epidemiology Gastrointestinal Diseases - prevention & control Health aspects health status human behavior human health Humans Illnesses Incidence infection Infectious diseases Internal Medicine Lactobacillus Lactobacillus casei Male Medicine Medicine & Public Health Metabolic Diseases Metropolitan areas Nutrition research Original original-article parents preschool children Prevention Probiotics Probiotics - therapeutic use Public Health randomized clinical trials Respiratory Tract Infections - epidemiology Respiratory Tract Infections - prevention & control school absences Schools |
| title | Use of a fermented dairy probiotic drink containing Lactobacillus casei (DN-114 001) to decrease the rate of illness in kids: the DRINK study A patient-oriented, double-blind, cluster-randomized, placebo-controlled, clinical trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T20%3A57%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Use%20of%20a%20fermented%20dairy%20probiotic%20drink%20containing%20Lactobacillus%20casei%20(DN-114%20001)%20to%20decrease%20the%20rate%20of%20illness%20in%20kids:%20the%20DRINK%20study%20A%20patient-oriented,%20double-blind,%20cluster-randomized,%20placebo-controlled,%20clinical%20trial&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Merenstein,%20D&rft.date=2010-07-01&rft.volume=64&rft.issue=7&rft.spage=669&rft.epage=677&rft.pages=669-677&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/ejcn.2010.65&rft_dat=%3Cgale_pubme%3EA231094518%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=580105884&rft_id=info:pmid/20485304&rft_galeid=A231094518&rfr_iscdi=true |