Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling

Numerous synthetic vitamin D analogs have been studied for their effects on the prevention and treatment of breast cancer. However, the inhibitory effects of naturally occurring 1α,25-dihydroxyvitamin D 3 or its synthetic analogs on ErbB2 overexpressing mammary tumorigenesis have not been reported....

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Veröffentlicht in:	Journal of steroid biochemistry and molecular biology 2010-07, Vol.121 (1), p.408-412
Hauptverfasser:	Lee, Hong Jin, So, Jae-Young, DeCastro, Andrew, Smolarek, Amanda, Paul, Shiby, Maehr, Hubert, Uskokovic, Milan, Suh, Nanjoo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcitriol - analogs & derivatives Calcitriol - pharmacology Calcium - metabolism Carcinogens Cell Line, Tumor Cell Proliferation Cholecalciferol - analogs & derivatives ErbB2 Fundamental and applied biological sciences. Psychology Gemini vitamin D Mammary Neoplasms, Animal - metabolism Mammary tumorigenesis Mice Mice, Transgenic Microscopy, Fluorescence - methods Mitogen-Activated Protein Kinase 3 - metabolism Neu Proto-Oncogene Proteins c-akt - metabolism Receptor, ErbB-2 - metabolism Signal Transduction Vertebrates: endocrinology Vertebrates: reproduction
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