Identification of MicroRNA-93 as a Novel Regulator of Vascular Endothelial Growth Factor in Hyperglycemic Conditions

Vascular endothelial growth factor (VEGF) is a dimeric glycoprotein that plays a crucial role in microvascular complications of diabetes, including diabetic nephropathy. However, the precise regulatory mechanisms governing VEGF expression in the diabetic milieu are still poorly understood. Here, we...

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Veröffentlicht in:	The Journal of biological chemistry 2010-07, Vol.285 (30), p.23457-23465
Hauptverfasser:	Long, Jianyin, Wang, Yin, Wang, Wenjian, Chang, Benny H.J., Danesh, Farhad R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Base Sequence Cell Cycle Proteins - genetics Diabetes Diabetes Mellitus - genetics Diabetes Mellitus - metabolism Diabetes Mellitus - pathology Diabetes Mellitus - physiopathology DNA-Binding Proteins - genetics Dose-Response Relationship, Drug Down-Regulation - drug effects Endothelial Cells - drug effects Endothelial Cells - metabolism Gene regulation Glucose - pharmacology Growth factors HeLa Cells Humans Hyperglycemia - genetics Hyperglycemia - metabolism Hyperglycemia - pathology Hyperglycemia - physiopathology Kidney Mice MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Microvessels - cytology Minichromosome Maintenance Complex Component 7 Molecular Bases of Disease Molecular Sequence Data Morpholines - chemistry Morpholines - pharmacology Nuclear Proteins - genetics Podocytes - cytology Podocytes - drug effects Podocytes - metabolism Podocytes - pathology Polymers - chemistry Promoter Regions, Genetic - genetics Reproducibility of Results Signal Transduction Transcription, Genetic Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism VEGF
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