Growth Factor Stimulation Induces Cell Survival by c-Jun·ATF2-dependent Activation of Bcl-XL

Growth factor stimulation induces c-Jun-dependent survival of primary endothelial cells. However, the mechanism of c-Jun anti-apoptotic activity has not been identified. We here demonstrate that in response to growth factor treatment, primary human endothelial cells as well as mouse fibroblasts resp...

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Veröffentlicht in:	The Journal of biological chemistry 2010-07, Vol.285 (30), p.23096-23104
Hauptverfasser:	Salameh, Ahmad, Galvagni, Federico, Anselmi, Francesca, De Clemente, Caterina, Orlandini, Maurizio, Oliviero, Salvatore
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 2 - chemistry Activating Transcription Factor 2 - deficiency Activating Transcription Factor 2 - genetics Activating Transcription Factor 2 - metabolism Animals AP-1 Transcription Factor Apoptosis - drug effects Base Sequence bcl-X Protein - genetics bcl-X Protein - metabolism Binding Sites Cell Line Cell Survival - drug effects Coregulator Transcription Endothelial Cells - cytology Endothelial Cells - drug effects Endothelial Cells - metabolism Endothelium Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Expression Regulation - drug effects Gene Regulation Gene Silencing Humans Intercellular Signaling Peptides and Proteins - pharmacology JNK Mitogen-Activated Protein Kinases - chemistry JNK Mitogen-Activated Protein Kinases - deficiency JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism Jun Transcription Factor Mice Protein Multimerization Protein Structure, Quaternary Signal Transduction - drug effects Transcription Factor AP-1 - metabolism Transcription Factors Transcription Regulation Transcription, Genetic
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