Trastuzumab induced in vivo tissue remodelling associated in vitro with inhibition of the active forms of AKT and PTEN and RhoB induction in an ovarian carcinoma model

Background: The incidence of ovarian cancer has been increasing worldwide and it is currently the leading cause of death from gynaecological malignancy. Unlike breast cancer, the prognostic role of the human epidermal growth factor receptor-2 (HER-2) in ovarian carcinoma remains controversial. Metho...

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Veröffentlicht in:	British journal of cancer 2010-06, Vol.103 (1), p.61-72
Hauptverfasser:	Delord, J-P, Quideau, S, Rochaix, P, Caselles, O, Couderc, B, Hennebelle, I, Courbon, F, Canal, P, Allal, B C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/609 692/308/2778 692/699/67/1517/1709 Animals Antibodies Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - pharmacology Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Cancer Research Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cyclin-Dependent Kinase Inhibitor p27 - analysis Cytoskeleton - chemistry Cytoskeleton - drug effects Disease Models, Animal Drug Resistance Epidemiology Epidermal growth factor Female Female genital diseases Gene amplification Gynecology Gynecology. Andrology. Obstetrics Humans Kinases Laboratory animals Medical prognosis Medical research Medical sciences Metastasis Mice Molecular Medicine Oncology Ovarian cancer Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Peritoneum - drug effects Peritoneum - metabolism Permeability Phosphatase Proteins Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - physiology PTEN Phosphohydrolase - antagonists & inhibitors PTEN Phosphohydrolase - physiology Receptor, ErbB-2 - analysis rhoB GTP-Binding Protein - physiology Signal transduction Translational Therapeutics Trastuzumab Tumors
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